SYNTHESIS AND MOLECULAR DOCKING STUDIES ON BIOLOGICALLY ACTIVE PYRAZOLE TERMINATED IMINO NAPHTHYL DERIVATIVES-Reference-Cited by-同舟云学术

SYNTHESIS AND MOLECULAR DOCKING STUDIES ON BIOLOGICALLY ACTIVE PYRAZOLE TERMINATED IMINO NAPHTHYL DERIVATIVES

Published:2022-11-01 Issue:09 Volume:59 Page:41-49
ISSN:0019-462X
Container-title:Indian Drugs
language:
Short-container-title:IND. DRU.

Author:

P. Veetil Sandhya, ,R. Karickal Haridas

Abstract

In this present study, a series of pyrazole terminated imino naphthyl derivatives were synthesized by the condensation reaction between 1,3 - diphenyl pyrazol-4-carboxaldehyde with substituted aromatic amines. The compounds were analyzed for their in vitro antimicrobial activities against some bacterial and fungal species and compared with the standard drugs. The molecular docking studies with protein and DNA were also carried out and revealed that all the synthesized compounds showed moderate to good biological activities, both experimentally and theoretically.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

Link

https://www.indiandrugsonline.org//download/September_2022_59_9_41-49.pdf

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