METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY-Reference-Cited by-同舟云学术

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY

Published:2023-07-28 Issue:07 Volume:60 Page:93-95
ISSN:0019-462X
Container-title:INDIAN DRUGS
language:
Short-container-title:IND. DRU.

Author:

B. Akhil M., ,Kutty Sheeja V.,Haribabu Yellina,K Nihila

Abstract

A simple, accurate, precise and economical method has been developed for the simultaneous estimation of pregabalin and etoricoxib in combined dosage form by using double point standardization method. Methanol is used as the solvent and chromogenic agent added was bromocresol green. Bromocresol green is only reactive with pregabalin form a green colour ion pair complex. l max of pregabalin and etoricoxib was at 618 nm and 235 nm, respectively. The method was found to be linear in the range of 6-22 µg mL-1 for pregabalin and 4.8-17.6 µg mL-1 for etoricoxib. Validation parameters was performed and method was found to be linear, accurate, precise, rugged and robust.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

Link

https://www.indiandrugsonline.org//download/July_2023_60_7_93-95.pdf

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