Author:
Phaugat Parmita, ,Dhall Manish,Nishal Suchitra
Abstract
The transdermal drug administration system represents a potent substitute for administering medications orally and is also designed to offer a substitute for hypodermic injections. Presently, three generations of penetration enhancer to permeate through skin are available 1st Generation embraces chemical approaches and pertain to augment the efficacy of the drug transferred across the integral skin, 2nd generation encompasses physical permeation technologies and 3rd generation consists of microneedle and needleless penetration enhancers. There is renewed interest in transdermal drug delivery. This review focuses on some existing novel approaches and the additive upshot of techniques for increasing the permeation of drugs via skin penetration. By using the right methods, drug carriers, or certain chemical agents, it is important to cause the stratum corneum to change physically or biomolecularly.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
Reference103 articles.
1. 1. Alkilani A. Z., McCrudden M. T. and Donnelly R. F.: Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum, Pharmaceutics., 2015, 7(4), 438-470.
2. 2. Sashikant D. and Mrugendra B.: Formulation of transdermal patch of carvedilol by using novel polymers, Der Pharmacia Sinica, 2011, 2 (2), 185-189.
3. 3. Kumar R. and Philip A.: Modified transdermal technologies: Breaking the barriers of drug permeation via the skin, Trop. J. Pharm. Res., 2007, 6(1), 633-644.
4. 4. Patel H. J., Trivedi D. G., Bhandari A. K. and Shah D. A.: Penetration enhancers for transdermal drug delivery system: A review, IJPI's J. Pharmaceut. Cosmetol., 2011, 1(2), 67-80.
5. 5. Rao R., Mahant S., Chhabra L. and Nanda S.: Transdermal innovations in diabetes management, Curr. Diabetes Rev., 2014, 10(6), 343-359.