Implementing the Biopharmaceutics Classification System in Drug Development: Reconciling Similarities, Differences, and Shared Challenges in the EMA and US-FDA-Recommended Approaches

Author:

Cardot J.-M.,Garcia Arieta A.,Paixao P.,Tasevska I.,Davit B.

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference16 articles.

1. Amidon GL, Lennerhas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 1995;12:413–20.

2. Amidon KS, Langguth P, Lennernäs H, Yu L, Amidon GL. Bioequivalence of oral products and the biopharmaceutics classification system: science regulation and public policy. Clin Pharmacol Ther. 2011;90:467–70. doi: 10.1038/clpt.2011.109 .

3. European Medicines Agency. CPMP/EWP/QWP/1401/98 Rev. 1 Committee for medicinal products for human use (CHMP) guideline on the investigation of bioequivalence. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/01/WC500070039.pdf (2010). Accessed 15 Feb 2016.

4. World Health Organization. WHO Technical Report Series No. 992 Annex 7. Multisource (Generic) pharmaceutical products: guidelines on registration requirements to establish interchangeability. http://apps.who.int/medicinedocs/documents/s21891en/s21891en.pdf (2015). Accessed 15 Feb 2016.

5. U.S. Food and Drug Administration. Draft guidance for industry waiver of in vivo bioavailability and bioequivalence studies for immediate-release solid oral dosage forms based on a biopharmaceutics classification system. http://www.fda.gov/downloads/Drugs/…/Guidances/ucm070246.pdf (2015). Accessed 15 Feb 2016.

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