Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): Preliminary in vivo evaluation of efficacy and toxicity using a canine model

Author:

Chang Li-Chien,Wrobleski Shirley,Wakefield Thomas W.,Lee Lai Ming,Yang Victor C.

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference26 articles.

1. Ando T, Yamasaki M, Suuzuki K. In: Kleinzeller A, ed. Protamine Molecular Biology, Biochemistry and Biophysics, Vol 12, New York: Springer-Verlag. 1973;1–109.

2. Metz S, Horrow JC. Protamine and newer heparin antagonists. In: Stoelting RK, eds Pharmacology and Physiology in Anesthetic Practice Vol 1 No 3. Fliadelphia, Pa: JB Lippincott, 1994;1–15.

3. Weiler JM, Gelhaus MA, Carter JG, et al. Serious adverse reactions to protamine sulfate: are alternatives needed?. J Allergy Clin Immunol. 1985;75:297–303.

4. Horrow JC. Protamine: a review of its toxicity. Anesth Analg. 1985;64:348–361.

5. Porsche R, Brenner ZR. Allergy to protamine sulfate. Heart Lung: J Acute Crit Care. 1999, 28:418–428.

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