Affiliation:
1. Department of Epidemiology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Poland
Abstract
The protective effect of selenium against colorectal cancer or adenoma is still a controversial
issue. Although there are well-described (pato)physiological protective mechanisms of selenium
against colorectal cancer, the results of the studies from 1998-2018 are inconclusive and
need to be considered in the future. Neither observational nor experimental studies present
consistent results. Although the Cochrane review showed that well-designed randomized
clinical trials (RCTs) presented no beneficial effect of selenium supplementation on cancer
incidence, well-designed RCTs confirming the protective effect of selenium supplementation
against colorectal adenoma or colorectal polyp recurrence have been found in subject-related
literature.
In the reviewed studies, selenium concentration was measured in the blood serum/toenail or
in diet. It is of great importance to highlight that blood selenium concentration depends on
the concentration of this micronutrient in food, which in turn depends on selenium content in
soil, bioavailability of selenium, which is different in various geographical regions, and forms
of selenium. Selenium circulating in blood as a component of selenoproteins participates in
oxidoreduction, thus reducing the risk of developing colorectal cancer. Despite this well-known
protective mechanism against colorectal cancer occurrence, half of the reviewed studies did
not confirm the protective properties of selenium.
To sum up, the current state of knowledge on the association between selenium and colorectal
cancer or adenoma has revealed not only inconclusive results of the studies, but has also shown
that there is a need to conduct more prospective studies focused on selenium supplementation
and colorectal cancer as this research is limited.
Subject
Infectious Diseases,Microbiology (medical)
Cited by
3 articles.
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