Polymorphism of genes of immune-inflammatory response, thrombophilia, and arterial hypertension in kidney diseases in children (literature review)-Reference-Cited by-同舟云学术

Polymorphism of genes of immune-inflammatory response, thrombophilia, and arterial hypertension in kidney diseases in children (literature review)

Published:2022-09-09 Issue:3 Volume:26 Page:40-51
ISSN:2541-9439
Container-title:Nephrology (Saint-Petersburg)
language:
Short-container-title:Nefrologiâ (St.-Peterbg.)

Author:

Vyalkova A. A.¹^ORCID,Zorin I. V.¹^ORCID,Karymova G. K.¹^ORCID,Chesnokova S. A.¹^ORCID

Affiliation:

1. Orenburg State Medical University

Abstract

Modern scientific data and the emergence of new opportunities for the development of pediatrics and nephrology are inextricably linked with medical genetics, the role of which is especially important for understanding the etiology and pathogenesis of many diseases of the urinary system. In 35–80 % of children with diffuse connective tissue diseases, kidney damage is formed, which is one of the leading causes of comorbidity of pathology and mortality of patients. Modern genetic research will allow not only to decipher the nature of diseases but also to scientifically substantiate adequate therapy. The active development of methods for the molecular diagnosis of kidney diseases opens up a large section of medicine, which can be called "molecular nephropathology". Further study of kidney diseases from the standpoint of molecular biology will allow us to take a fresh look at the pathogenesis of many diseases and solve a number of problems from the standpoint of personalized therapy, which takes into account the genetic characteristics of the patient. The active development of genetic research in nephrology has led to an understanding of the role of genetic mutations and polymorphisms leading to the occurrence of nephropathies in children. Correct clarification of the causes of the development of the disease can radically change the tactics of managing a patient by a nephrologist and rheumatologist. Determination of the genetic cause of the development of nephropathy is important in children since it justifies the need to examine other family members, it will allow predicting the risk of developing kidney pathology in diffuse connective tissue diseases, which is very important, predicting the response to immunosuppressive therapy. The development of molecular diagnostic methods is increasingly opening up prospects for a personalized approach to the study of pathology at various levels of interaction; these achievements provide a qualitative assessment of DNA, RNA, proteins, and their metabolites, which makes it possible to determine new biomarkers. The article deals with gene polymorphisms in secondary nephropathies in children with diffuse connective tissue diseases (systemic lupus erythematosus, systemic microthrombovasculitis, rheumatoid arthritis).

Publisher

Non-profit organization Nephrology

Subject

Nephrology

Reference64 articles.

1. Shchadneva S. I. Porazheniya pochek pri revmaticheskikh zabolevaniyakh / S. I. Shchadneva, A. N. Kalyagin // Sovremennye problemy revmatologii. – 2014. – 6 (6): 10–26 / Shchadneva S. I., Kalyagin A. N. Kidney damage in rheumatic diseases. Modern problems of rheumatology 2014; 6 (6): 10–26 (In Russ.)

2. Papayan K. A. Polimorfizm genov, assotsiirovannykh s nasledstvennoi trombofiliei, u patsientov s nefroticheskim sindromom, pervichnym i vtorichnym glomerulonefritom / K. A. Palayan [i dr.] // Nefrologiya. – 2015. – (3): 64–71 / Papayan K. A., Kapustin S. I., Savenkova N. D. et al. Polymorphism of genes associated with hereditary thrombophilia in patients with nephrotic syndrome, primary and secondary glomerulonephritis. Nephrology 2015; (3): 64–71 (In Russ.)

3. Coboleva M. K. Porazhenie pochek pri sistemnoi krasnoi volchanke u detei i podrostkov: osobennosti techeniya i iskhody / M. K. Coboleva, T. P. Simantovskaya, N. M. Sobol' // Pediatriya. Zhurnal im. G. N. Speranskogo. – 2012. –91 (6): 22–28 / Soboleva M. K., Simantovskaya T. P., Sobol N. M. Kidney damage in systemic lupus erythematosus in children and adolescents: course features and outcomes. Pediatrics. Journal named after G. N. Speransky 2012; 91 (6): 22–28 (In Russ.)

4. Lopes-Novoiya D. Etiopatologiya khronicheskoi tubulyarnoi, glomerulyarnoi i renovaskulyarnoi nefropatii: klinicheskie aspekty / D. Lopes-Novoiya // Nefrologiya. – 2013. – 17 (2): 9–38. URL: https://cyberleninka.ru/article/n/etiopatologiya-hronicheskoy-tubulyarnoy-glomerulyarnoy-i-renovaskulyarnoy-nefropatiy-klinicheskie-aspekty?ysclid=l7uira4ui0523227800 / Lopez-Novaya D., Rodriguez-Pena A., Ortiz A. et al. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical aspects. Nephrology 2013; 17 (2): 9–38 (In Russ.). URL: https://cyberleninka.ru/article/n/etiopatologiya-hronicheskoy-tubulyarnoy-glomerulyarnoy-i-renovaskulyarnoy-nefropatiy-klinicheskie-aspekty?ysclid=l7uira4ui0523227800

5. Pankov E. A. Osobennosti raspredeleniya polimorfnykh variantov genov, assotsiirovannykh s trombofiliei i arterial'noi gipertenziei u detei s gemolitikoremicheskim sindromom / E. A. Pankov [i dr.] // Nefrologiya. – 2020. – 24 (3): 90–94. doi: 10.36485/1561-6274-2020-24-3-90-94 / Pankov E. A., Papayan K. A., Kapustin S. I., Savenkova N. D. Distribution of polymorphic variants of genes associated with thrombophilia and arterial hypertension in children with hemolytic uremic syndrome. Nephrology 2020; 24 (3): 90–94. doi: 10.36485/1561-6274-2020-24-3-90-94 (In Russ.)