Features of intrarenal hemodinamics as endotelial dysfunction indicator in patients with coronary heart disease in the post-COVID-19 period

Abstract

BACKGROUND. Coronary heart disease (CHD) and obesity are common pathologies in patients who have had COVID-19. Endothelial dysfunction (ED) markers determination has been important in such patients due to the high risk of cardiovascular diseases progression and complications development.THE AIM Assessment of endothelial dysfunction severity in patients with CHD and obesity in the post-COVID-19 period to improve the management of these patients.PATIENTS AND METHODS. 49 patients were examined, who had COVID-19 a year ago. The first group (n=24) included patients with coronary artery disease in the post-COVID period. The second group (n=25) included patients with CHD and obesity who had COVID-19. We evaluated data from an ultrasound examination of the kidneys with duplex scanning of the renal arteries (resistance index (RI), pulsation index (PI)). We also studied the medical history, performed an objective examination, the results of a biochemical blood test, albuminuria levels.RESULTS. We demonstrated higher RI and PI of interlobar, segmental arteries in persons of the second group. An increase in RI and PI of segmental arteries accompanied by an increase in uric acid (p=0.001). The average level of microalbuminuria in the first group was 15,71± 4,51 μg/l, in the second group it was 24,38±5,38 μg/l (p=0.110). Increasing glucose levels accompanied by an elevation of C-reactive protein levels. Obesepatients had significantly higher levels of total cholesterol, triglycerides, low density lipoproteins than patients in the first group.CONCLUSION. We observed changes in lipid metabolism, a higher incidence of diabetes mellitus in females, and changes in intrarenal hemodynamic parameters associated with uric acid levels in patients with coronary heart disease and obesity in the post-COVID-19 period.