Using kefir glucomannan to modify the diversity and composition of cecum bacterial in Sprague Dawley rats with metabolic syndrome

Abstract

Abstract This study aimed to determine the effect of kefir and kefir glucomannan (Kefir-GM) to the diversity and composition cecum bacteria and bodyweight and feed intake in rat metabolic syndrome. Research carried out used four group’s treatment, namely (1) control, normal rat (2) rats with metabolic syndrome (3) diet kefir in rats with metabolic syndrome, and (4) diet kefir-GM in rats with metabolic syndrome. After 4 weeks, cecum was taken for analysis of the diversity and composition of bacterial. Kefir and Kefir-GM in rats metabolic syndrome did not significantly affect the diversity at p<0.05, but increased Lactobacillus 14.61% and Bifidobacterium 2.2%, and decreased Clostridium 38.15% and Bacteroides 22.51%. Bodyweight and feed intake did not significantly different at p<0.05. Based on this research, kefir and Kefir-GM did not affect diversity but it is able to modify composition bacteria on cecum and also can keep the bodyweight and feed intake in rats.