Nanotoxicological Aspects of Post-Ischemic Myocardium Reconstruction

Abstract

Abstract Selenium (Se) is an essential atom in living organisms but some aspects of its metabolism and function remain unknown. Se large deficiencies cause significant disturbances of cardiovascular system and left ventricle (LV) fibrosis. The studies are needed to characterize the significance of Se in post-infarct LV dysfunction and postoperative remodeling. In Tomsk region, the level of Se in hair of healthy people and in myocardium of patients with ischemic cardiomyopathy was not changed. Chemical analysis of hair samples and myocardium of LV for Se content was based on a stripping voltammetry for determining the mass concentrations of this microelement. Nevertheless, a significant number of cardiac surgical patients showed a negative dynamics of postoperative LV myocardial remodeling with progression of heart failure. We obtained preliminary results on the direct relationship between favorable outcomes of postoperative adaptive myocardial remodeling (AR) and maladaptive myocardial remodeling (MALR) with variations in Se concentrations in the myocardium. At the same time, there were 84 % of cases with abnormal postoperative MALR of LV in the presence of extremely high (toxic) Se content in the myocardium. Further in-depth studies are required to translate novel data from the laboratory bench to the clinics.