The potency of Polylathia longifolia from Indonesia and the Philippines as therapeutic agents on inflammatory bowel disease (IBD) in Rats (Rattus norvegicus) induced by Indomethacin

Abstract

Abstract Herbal medicines have the potential to be used as therapeutic agents. Polyalthia longifolia is widely grown in both Indonesia and the Philippines, but it has not commonly used for its therapeutic purposes. Some studies reported that P. longifolia leaves extract has anti-inflammatory activity. In this study, the potential of Polyalthia longifolia leaves extracts for inflammatory bowel disease (IBD) in Indometachin-induced rats was tested. Four groups of rats were used for this research, were control (T1), rats with IBD with 10 mg/kg BW of sulfasalazine therapy (T2),) rats with IBD treated with 300 mg/kg BW of Indonesia P. longifolia leaves extract therapy (T3) and rats IBD treated with 300mg/kg BW of The Philippines P. longifolia leaves extract therapy (T4). Histopathology of gastric, duodenum, jejunum, and colon were analyzed, with protein profile and pro-inflammatory cytokines expressions. The results showed that P. longifolia leaves extract therapy origin from Indonesia and the Philippines were potent as anti-inflammatory agents comparable to commercially available drugs against IBD. This works proposed the use of P. longifolia leaves as IBD therapy.