Development Method for Determination of Aspirin as Sodium Salicylate by UV-VIS Spectroscopy

Abstract

Abstract New, easy and quick way to signal U.V. – Vis. spectroscopy was developed and validated for the estimation of Aspirin in pure form, and in respective formulations. The appropriate solubility of the drug and the maximum sensitivity of the assay were found as Salicylate, the peak of maximum absorbance of Salicylate was appear at (535 nm) in the wavelength scope of (300-900 nm); The linear calibration curve of aspirin concentrations range (10-80 ppm) are shown to show the regression equation (Y=0.0086X - 0.0429), and correlation Coefficient (R2 = 0.9999), the LOQ for Aspirin was up to (5.43742 – 0.306928 mg.L−1), while LOD were (1.794348 - 0.101286 mg.L−1). This method has been validated and applied to the estimate of aspirin from various companies in Iraqi marts, no intrusions was found from tablet of aspirin excipients at the favored wavelength and conditions of estimate; Concluded that the method developed was perfect, precise, accurate, and replicable. As well as it can be directly applied to determine Salicylate and indirectly for the estimation of Aspirin content in pharmaceutical formulations, by calibration curve method or standard addition method.