Extraction of phenolic compounds from Iraqi Coriandrum Sativum L. and loaded on copolymeric hydrogels and examine there as drug delivery system and antioxidant

Abstract

Abstract The phenolic extracts for leaves and stems (L+S) parts and leaves (L) part of Iraqi Coriandrum Sativum L. and their total phenols, total tannins and total flavonoids are described. Three copolymeric hydrogels prepared and loaded with phenolic extract 4 (U1-U3). The HPLC results show three phenolic compounds, while the GC-Mass results show one phenolic compound and four non-phenolic compounds. Gained results showed that there are significant (P < 0.05) variations in total phenols (9.822 ± 0.634−4.015 ± 0.118 mg GAE/g DW), total flavonoids (8.112 ± 0.115−2.811 ± 0.371 mg QE/g DW) and total condensed tannin (4.245 ± 0.276−1.135 ± 0.091 mg QE/g DW) contents for all phenolic extracts. The swelling rate for (U1-U3) in distilled water, the SGF, and the SIF was estimated. The maximum swelling was observed in copolymeric hydrogels at pH 6.9 in distilled water. The IC50 values of radical scavenging activity of the phenolic extracts 4, 8 and phenolic extract 4 released from copolymeric hydrogels (U1-U3) show varied significantly (P < 0.05). Our results indicated that Iraqi Coriandrum Sativum L. could constitute a rich and novel source of natural antioxidants. When it loaded on, copolymeric hydrogels could be used as a drug delivery system.