Problems and methods of a closed-loop blood glucose control system construction

Abstract

Abstract The automation of the insulin therapy in the closed-loop blood glucose control system is accompanied by such problems as delays of the feedback and the controlling action effect on blood glucose dynamics, difficulties in low and high glucose levels advance detection and timely compensation, a human factor, complexity of a mathematical model of control object building, evaluation of blood glucose control efficiency. In the paper, these automation problems and methods for their compensation are considered. The closed-loop system based on the model predictive control, adaptive adjustment of the controlling action and decision-making support was developed. Experimental testing with UVA/Padova Type 1 Diabetes Mellitus Simulator showed that the application of suggested methods in the closed-loop allows increasing the efficiency of the blood glucose maintaining in the target range.