Organophospate exposure time impact on acetylcholin-esterase activity

Abstract

Abstract This study aimed to determine exposure time needed by organophosphate pesticides (OPs) to decrease acetilcholinesterase (AChE) activity in wistar rats. Twenty-five male were divided into 5 groups. The control group without OPs exposure (K0), the group exposed to OPs for 1 week (K1), and groups (K2), (K3) and (K4) exposed to OPs for 2,3, and 4 weeks respectively. The blood sample was taken every week and the AChE activity of blood sample was measured using a spectrophotometer. The results showed that AChE activity decreased with the longer OPs exposure time. Exposed treatment for 3 weeks (K3) 162.80 ± 4.56 U/L showed a significant difference (p <0.05) on control (K0) 499.20±6.99 U/L. The results showed that the AChE activity of (K3) significanly decreased 162,80±4,56 U/L compared to control (K0) 499.20 ± 6.99 U/L. In conclusion Exposure OPs pesticide 3 weeks can reduce AChE activity.