Poly(L-lactide-co-ε-caprolactone) Nanofiber Morphology Control and Influence of Properties

Abstract

Abstract Electrospinning has the advantages of large specific surface area and high porosity, and the nanofibers prepared by it can be widely used in environmental engineering, wound dressing, scaffold materials, biomedicine and other fields. Because gelatin is a biological material with biodegradable and good biocompatibility properties; while poly(L-lactide-co-ε-caprolactone) (PLCL) is a biological material with excellent mechanical properties and good biocompatibility. Therefore, the prepared PLCL/gelatin nanofiber membrane has good biocompatibility, and has minimal repellency to the body during clinical use, and is effective as a scaffold material. This article uses PLCL and gelatin as experimental materials to study the development and optimization of fiber scaffold materials. First introduce the existing tissue engineering scaffold materials, and then describe the basic principles of electrospinning technology. Used 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent to prepare PLCL/GE spinning solution and prepare nanofiber membranes with different total concentrations and different ratios of PLCL to GE, then used the electrospinning process as preparation method to spin nanofiber membranes separately, and the microstructure and hydrophobic performance parameters of the nanofibers were tested and characterized.