Preparation characterization and application of Chitosan nanoparticles as drug carrier

Abstract

Abstract To improve the therapeutic efficacy of Mebeverine Hydrochloride (MB.HCl) medication, this study was worked on by reducing the drug dosages while maintaining the level of the drug inside the patients’ body. The best treatment results are achieved by loading the drug through a medicated drug carrier that is Chitosan nanoparticle (CSNPs) and preparation was done by Ionic gelation method which including reaction between binding material Sodium tripolyphosphate (STPP) and Chitosan (CS) which was extracted from shrimp shells. The drug was loaded by Chitosan nanoparticles and the proof was done by using several techniques, namely FT-IR and X-ray diffraction spectrum, the size of particles was determined before and after loading using Particle size analyzer, also use the FE - SEM emission electron scanning microscope where the results showed the success of preparing a drug carrier and MB.HCl was loading on Chitosan nanoparticles.