The genetic variant of GSTP1 and immune response of immunoglobulin A (IgA) on nasopharyngeal carcinoma patients

Abstract

Abstract GSTP1 polymorphism is one of the genetic factors contributed to (NPC). The polymorphism alters its function in detoxifying carcinogen and inhibits oxidative stress. Oxidative stress induces EBV lytic reactivation and enhances IgA response. This study was aimed to analyze the association of GSTP1 polymorphism and serum IgA levels in NPC patients. The study was analytic research with a cross-sectional design. The samples were the blood of NPC patients who underwent PCR-RFLP-electrophoresis and ELISA method to identify GSTP1 polymorphism and IgA level. We found 21 (72.4%) patients with Ile/Val genotype, 6 (20.7%) patients with Ile/Ile, and 2 (6.9%) patients with Val/Val. Patients with elevated IgA levels were 21 (72.4%) patients. In this study, there was no significant association of GSTP1 polymorphism and serum IgA level. We found the GSTP1 polymorphism and serum IgA elevation in nasopharyngeal carcinoma patients, but there was no significant association between them. Future research with the inclusion of environmental risk data is needed as well as larger samples. The study may help to determine effective prevention, treatment, and monitoring therapy of nasopharyngeal carcinoma.