First identification of potential bioactive compounds from ethanol extracts of Lepista sordida from Indonesia

Abstract

Abstract Mushrooms species are well known to have a high potential for bioactive compounds for decades. In the era of modern technologies, it is possible to uncover and explore the hidden ethnopharmacological values, comprising complex bioactive compounds of substantial health benefits. Lepista sordida is an edible and medicinal mushroom, and its distributed from Europe to Southeast Asia. However, there was no prior study on the bioactive compounds of L. sordida from Indonesia. In this present study, ethanol extracts of L. sordida were obtained and their extract properties were determined by gas chromatography-mass spectrometry (GC-MS). A total of 13 different chemical compounds were found in L. sordida ethanol extracts through GC-MS analysis. 4-O-Methylmannose, n-Hexadecanoic acid, and cis-13-Octadecenoic acid were noted as the major compounds with area percentages of 10.09%, 8.19%, and 6.49%, respectively. The result of PASS Server analysis suggested that the ethanolic extract of L. sordida has the pharmaceutical effect to treat phobic disorder and skin damage, preventing blood clotting, anti-inflammatory, and treating several infections which cause by bacteria, protozoa, and viruses. Therefore, it is strongly suggested to conduct further bioassay to confirm the pharmaceutical properties of this mushroom.