A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase-Reference-Cited by-同舟云学术

A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase

Published:2023-02-15 Issue:8 Volume:120 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Dhindwal Poonam¹^ORCID,Thompson Charis¹,Kos Daniel²,Planedin Koa²^ORCID,Jain Richa¹²,Jelinski Murray²^ORCID,Ruzzini Antonio¹³^ORCID

Affiliation:

1. Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada

2. Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada

3. Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada

Abstract

The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2219827120

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