Author:
Shannon Benjamin J.,Vaishnavi Sanjeev Neil,Vlassenko Andrei G.,Shimony Joshua S.,Rutlin Jerrel,Raichle Marcus E.
Abstract
Ten percent to 15% of glucose used by the brain is metabolized nonoxidatively despite adequate tissue oxygenation, a process termed aerobic glycolysis (AG). Because of the known role of glycolysis in biosynthesis, we tested whether learning-induced synaptic plasticity would lead to regionally appropriate, learning-dependent changes in AG. Functional MRI (fMRI) before, during, and after performance of a visual–motor adaptation task demonstrated that left Brodmann area 44 (BA44) played a key role in adaptation, with learning-related changes to activity during the task and altered resting-state, functional connectivity after the task. PET scans before and after task performance indicated a sustained increase in AG in left BA 44 accompanied by decreased oxygen consumption. Intersubject variability in behavioral adaptation rate correlated strongly with changes in AG in this region, as well as functional connectivity, which is consistent with a role for AG in synaptic plasticity.
Funder
HHS | NIH | National Institute of Neurological Disorders and Stroke
James S. McDonnell Foundation
Publisher
Proceedings of the National Academy of Sciences
Cited by
62 articles.
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