Proinsulin maturation, misfolding, and proteotoxicity
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference28 articles.
1. Unfolding of human proinsulin. Intermediates and possible role of its C-peptide in folding/unfolding
2. Proinsulin Disulfide Maturation and Misfolding in the Endoplasmic Reticulum
3. The unfolded protein response: A stress signaling pathway critical for health and disease
4. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 inIns2+/Akitapancreatic β cells
5. High ER stress in β-cells stimulates intracellular degradation of misfolded insulin
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