MicroRNA networks in FLT3-ITD acute myeloid leukemia-Reference-Cited by-同舟云学术

MicroRNA networks in FLT3-ITD acute myeloid leukemia

Published:2022-04-11 Issue:16 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Hoang Dinh Hoa¹,Zhao Dandan¹,Branciamore Sergio²^ORCID,Maestrini Davide²,Rodriguez Ivan R.¹^ORCID,Kuo Ya-Huei¹^ORCID,Rockne Russell²^ORCID,Khaled Samer K.¹,Zhang Bin¹,Nguyen Le Xuan Truong¹,Marcucci Guido¹³

Affiliation:

1. Gehr Family Center for Leukemia Research, City of Hope Medical Center, Hematologic Malignancies Research Institute and Center for Stem Cell Transplantation, Duarte, CA 91010

2. Department of Computational and Quantitative Medicine, Division of Mathematical Oncology and Computational Systems Biology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010

3. Department of Hematology & Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA 91010

Abstract

Significance We report on a deregulatory activity on microRNA (miRNA) biogenesis by the FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) in acute myeloid leukemia. FLT3-ITD provides a divergent signal for concurrent and aberrant miR-155 up-regulation and miR-126 down-regulation via a series of miRNA–protein regulatory loops interconnected through SH2-containing inositol phosphatase 1 (SHIP1)/phosphor-protein kinase B (AKT)/Sprouty related EVH1 domain containing 1 (SPRED1) signaling. This divergent input signal eventually converges and amplifies an output signal for leukemic growth.

Funder

HHS | National Institutes of Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2112482119

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