Prenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation-Reference-Cited by-同舟云学术

Prenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation

Published:2022-04-04 Issue:15 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Zhao Qiuying¹^ORCID,Dai Weiye²^ORCID,Chen Hui Yu³,Jacobs Russell E.¹^ORCID,Zlokovic Berislav V.¹,Lund Brett T.⁴,Montagne Axel⁵⁶^ORCID,Bonnin Alexandre¹^ORCID

Affiliation:

1. Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089

2. Master of Science, Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90089

3. Master of Medical Physiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089

4. Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089

5. UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, EH16 4SB Edinburgh, United Kingdom

6. Centre for Clinical Brain Sciences, Edinburgh BioQuarter, EH16 4SB Edinburgh, United Kingdom

Abstract

Significance This study demonstrates that maternal inflammation during pregnancy perturbs blood–brain barrier formation via cyclooxygenase activation in fetal microglia, leading to abnormal cerebrovascular function and chronic brain inflammation persisting across the offspring life span. Therefore, developmental disruption of blood–brain barrier formation could be an important etiological factor contributing to the pathology of neurodevelopmental disorders.

Funder

BrightFocus Foundation

HHS | NIH | National Institute of Mental Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2113310119

Reference70 articles.

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