Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs)-Reference-Cited by-同舟云学术

Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs)

Published:2022-01-24 Issue:5 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Madrigal Justin L.¹^ORCID,Schoepp Nathan G.¹^ORCID,Xu Linfeng²^ORCID,Powell Codian S.¹,Delley Cyrille L.²^ORCID,Siltanen Christian A.¹,Danao Jay³,Srinivasan Maithreyan¹,Cole Russell H.¹,Abate Adam R.²⁴

Affiliation:

1. Scribe Biosciences, San Francisco, CA 94107

2. Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158

3. Chimera Bioengineering, South San Francisco, CA 94080

4. Chan Zuckerberg Biohub, San Francisco, CA 94158

Abstract

Significance The study of specific cell–cell interactions at scale would be a significant advancement in single-cell biology with clear utility in immuno-oncology. Our development of Droplet Assembly provides a tool for such studies by extending the benefits of single-cell droplet microfluidics to high-order cell analyses. This technology allows for the construction, sorting, and downstream processing of cell–cell interactions and is compatible with single-cell genomic readouts.

Funder

Defense Sciences Office, DARPA

HHS | National Institutes of Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2110867119

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