A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals-Reference-Cited by-同舟云学术

A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals

Published:2022-02-07 Issue:7 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Eagles David A.¹^ORCID,Saez Natalie J.¹²,Krishnarjuna Bankala³^ORCID,Bradford Julia J.⁴^ORCID,Chin Yanni K.-Y.¹^ORCID,Starobova Hana¹^ORCID,Mueller Alexander¹^ORCID,Reichelt Melissa E.⁴,Undheim Eivind A. B.⁵⁶,Norton Raymond S.³⁷^ORCID,Thomas Walter G.⁴,Vetter Irina¹⁸^ORCID,King Glenn F.¹²^ORCID,Robinson Samuel D.¹^ORCID

Affiliation:

1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

2. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia

3. Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia

4. School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia

5. Centre for Biodiversity Dynamics, Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway

6. Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0316 Oslo, Norway

7. Australian Research Council Centre for Fragment-Based Design, Monash University, Parkville, VIC 3052, Australia

8. School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia

Abstract

Significance The targeting of mammalian ErbB receptor signaling by a venom toxin to cause hypersensitivity is a mode of action that has not previously been described. Natural selection of a defensive toxin to target ErbB signaling provides compelling independent evidence for a fundamental role of this receptor and its ligands in mammalian pain. The evolution of a toxin in ant venom to mimic a vertebrate nociceptive hormone serves as an example of both convergent evolution and molecular mimicry, illustrating how natural selection can shape the gene product of one organism to resemble that of another.

Funder

Australian Research Council

Department of Health | National Health and Medical Research Council

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2112630119

Reference54 articles.

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