A proposed unified mitotic chromosome architecture

Abstract

Significance The significance of this proposed mitotic chromosome architecture is that a specific, sequenced chromosome, human chromosome 10, can be built into a specific architecture that accounts for the dimensional values and cytological descriptions. Since this molecular architecture is an extension of the interphase chromosome structure, a coiling of the 11-nm nucleosome fiber with further coiling, a unifying molecular structure motif is present throughout the entire mitotic cycle, interphase through mitosis.