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A proposed unified mitotic chromosome architecture

Published:2022-05-11 Issue:20 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Sedat John¹,McDonald Angus²,Kasler Herbert³,Verdin Eric³,Cang Hu⁴,Arigovindan Muthuvel⁵,Murre Cornelis⁶,Elbaum Michael⁷^ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158

2. Micron School of Materials Science and Engineering, Boise State University, Boise, ID 83725-2090

3. Buck Institute for Research on Aging, Novato, CA 94945

4. Salk Institute for Biological Studies, La Jolla, CA 92037

5. Department of Electrical Engineering, Indian Institute of Science, Bengluru 560012, India

6. Division of Biological Sciences, University of California San Diego, La Jolla, CA 92092

7. Department of Chemical and Biological Physics, Weizmann Institute of Science, 760001 Rehovot, Israel

Abstract

Significance The significance of this proposed mitotic chromosome architecture is that a specific, sequenced chromosome, human chromosome 10, can be built into a specific architecture that accounts for the dimensional values and cytological descriptions. Since this molecular architecture is an extension of the interphase chromosome structure, a coiling of the 11-nm nucleosome fiber with further coiling, a unifying molecular structure motif is present throughout the entire mitotic cycle, interphase through mitosis.

Funder

ROIA

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2119107119

Reference30 articles.

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2. Wikipedia Slinky. https://en.wikipedia.org/wiki/Slinky. Accessed 28 April 2022.

3. Archaeal chromatin ‘slinkies’ are inherently dynamic complexes with deflected DNA wrapping pathways