Affiliation:
1. Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany
2. Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
Abstract
There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative,
Nature
600, 472–477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Pääbo,
Nature
587, 610–612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an ∼27% lower risk of HIV infection.
Funder
Magnus Bergvalls Stiftelse
Jeanssons Stiftelser
Vetenskapsrådet
Publisher
Proceedings of the National Academy of Sciences
Cited by
16 articles.
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