IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines-Reference-Cited by-同舟云学术

IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines

Published:2022-02-04 Issue:6 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Song Na-Young¹,Li Xin¹,Ma Buyong²^ORCID,Willette-Brown Jami¹,Zhu Feng¹,Jiang Chengfei³,Su Ling⁴,Shetty Jyoti⁴,Zhao Yongmei⁴,Shi Gongping¹^ORCID,Banerjee Sayantan¹,Wu Xiaolin⁴,Tran Bao⁴,Nussinov Ruth²,Karin Michael⁵^ORCID,Hu Yinling¹^ORCID

Affiliation:

1. Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD 21702

2. Laboratory of Cancer Immunometabolism, Frederick National Laboratory for Cancer Research, Frederick, MD 21702

3. Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892

4. Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701

5. Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, CA 92093

Abstract

Significance This study reveals that impaired IKKα expression or activity in lung cancer enhances differentiation of protumorigenic Treg cells through a TNF/TNFR2/NF-κB signaling pathway in both human and mouse lung ADC. Depletion of one of the molecules that are required for Treg cell induction represses lung ADC development. Thus, the components that interfere with this particular Treg differentiation provide targets for the generation of TME-modifying therapies.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2120956119

Reference54 articles.

1. Precision Diagnosis and Treatment for Advanced Non–Small-Cell Lung Cancer

2. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

3. PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions

4. IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways

5. Macrophage inducible nitric oxide synthase promotes the initiation of lung squamous cell carcinoma by maintaining circulated inflammation

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular interactions;Cancer Letters;2024-03

2. Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA;Cancer Gene Therapy;2023-11-21

3. TNFR1 and TNFR2, Which Link NF-κB Activation, Drive Lung Cancer Progression, Cell Dedifferentiation, and Metastasis;Cancers;2023-08-28

4. Cold atmospheric plasma: Novel opportunities for tumor microenvironment targeting;Cancer Medicine;2023-02-10

5. Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA;2022-11-30