Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci-Reference-Cited by-同舟云学术

Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci

Published:2022-05-23 Issue:22 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Ying Ying¹²,Wang Maolin¹³,Chen Yongheng¹,Li Meiqi¹,Ma Canjie¹,Zhang Junbao¹,Huang Xiaoyan¹,Jia Min¹,Zeng Junhui¹,Wang Yejun¹,Li Lili⁴^ORCID,Wang Xiaomei¹,Tao Qian⁴,Shu Xing-sheng¹²^ORCID

Affiliation:

1. School of Medicine, Health Science Center, Shenzhen University, Shenzhen 518060, China

2. Marshall Laboratory of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China

3. College of Pharmacy, Shenzhen Technology University, Shenzhen, 518000, China

4. Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 00000, China

Abstract

Significance This study uncovered the role of ZNF280C, a known DNA damage response protein, as a tumorigenic transcription regulator that contributes to colorectal tumorigenesis and metastasis through maintaining an epigenetic repression program at key cancer gene loci. These findings identified a contributor with potential prognostic value to colorectal pathogenesis and provide mechanistic insight to the essential function of transcription factor in fine-tuning the activity of chromatin regulators for proper transcription control.

Funder

National Natural Science Foundation of China

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2120633119

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