DNA methylation clocks for dogs and humans-Reference-Cited by-同舟云学术

DNA methylation clocks for dogs and humans

Published:2022-05-17 Issue:21 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Horvath Steve¹²^ORCID,Lu Ake T.¹,Haghani Amin¹,Zoller Joseph A.²,Li Caesar Z.²,Lim Andrea R.¹,Brooke Robert T.³,Raj Ken⁴,Serres-Armero Aitor⁵,Dreger Dayna L.⁵^ORCID,Hogan Andrew N.⁵,Plassais Jocelyn⁵,Ostrander Elaine A.⁵^ORCID

Affiliation:

1. Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095

2. Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095

3. Epigenetic Clock Development Foundation, Los Angeles, CA 90502

4. Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot OX11 0RQ, United Kingdom

5. National Human Genome Research Institute, NIH, Bethesda, MD 20892

Abstract

Significance Epigenetic estimators of age (known as clocks) allow one to identify interventions that slow or reverse aging. Previous epigenetic clocks only applied to one species at a time. Here, we describe epigenetic clocks that apply to both dogs and humans. These clocks, which measure methylation levels in highly conserved stretches of the DNA, promise to increase the likelihood that interventions that reverse epigenetic age in one species will have the same effect in the other.

Funder

HHS | NIH | National Institute of Mental Health

HHS | NIH | National Institute of Neurological Disorders and Stroke

Manhattan HIV Brain Bank

Texas NeuroAIDS Research Center

National Neurological AIDS Bank

California NeuroAIDS Tissue Network

HHS | NIH | National Cancer Institute

HHS | NIH | National Human Genome Research Institute

Publisher

Proceedings of the National Academy of Sciences

Subject