Pathogen prospecting of museums: Reconstructing malaria epidemiology-Reference-Cited by-同舟云学术

Pathogen prospecting of museums: Reconstructing malaria epidemiology

Published:2024-03-25 Issue:15 Volume:121 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Nelder Mark P.¹^ORCID,Schats Rachel²^ORCID,Poinar Hendrik N.³⁴⁵^ORCID,Cooke Amanda³^ORCID,Brickley Megan B.³^ORCID

Affiliation:

1. Enteric, Zoonotic and Vector-Borne Diseases, Health Protection, Public Health Ontario, Toronto, ON M5G 1M1, Canada

2. Laboratory for Human Osteoarchaeology, Faculty of Archaeology, Leiden University, 2333 CC Leiden, The Netherlands

3. Department of Anthropology, McMaster University, Hamilton, ON L8S 4L9, Canada

4. Department of Biochemistry, McMaster University, Hamilton, ON L8S 4L9, Canada

5. McMaster Ancient DNA Centre, Department of Anthropology, McMaster University, Hamilton, ON L8S 4L9, Canada

Abstract

Malaria is a disease of global significance. Ongoing changes to the earth’s climate, antimalarial resistance, insecticide resistance, and socioeconomic decline test the resilience of malaria prevention programs. Museum insect specimens present an untapped resource for studying vector-borne pathogens, spurring the question: Do historical mosquito collections contain Plasmodium DNA, and, if so, can museum specimens be used to reconstruct the historical epidemiology of malaria? In this Perspective, we explore molecular techniques practical to pathogen prospecting, which, more broadly, we define as the science of screening entomological museum specimens for human, animal, or plant pathogens. Historical DNA and pathogen prospecting provide a means of describing the coevolution of human, vector, and parasite, informing the development of insecticides, diagnostics, therapeutics, and vaccines.

Funder

Canada Research Chairs

Dutch Research Council

Elise Mathilde Fund/Leiden University Fund

Publisher

Proceedings of the National Academy of Sciences

Link

https://pnas.org/doi/pdf/10.1073/pnas.2310859121

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