Consciousness is supported by near-critical slow cortical electrodynamics

Author:

Toker Daniel1,Pappas Ioannis234,Lendner Janna D.25ORCID,Frohlich Joel1ORCID,Mateos Diego M.678ORCID,Muthukumaraswamy Suresh9,Carhart-Harris Robin1011,Paff Michelle12ORCID,Vespa Paul M.13,Monti Martin M.113ORCID,Sommer Friedrich T.214,Knight Robert T.23ORCID,D’Esposito Mark23

Affiliation:

1. Department of Psychology, University of California, Los Angeles, CA 90095

2. Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94704

3. Department of Psychology, University of California, Berkeley, CA 94704

4. Laboratory of Neuro Imaging, Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033

5. Department of Anesthesiology and Intensive Care, University Medical Center, 72076 Tübingen, Germany

6. Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, C1425 Buenos Aires, Argentina

7. Facultad de Ciencia y Tecnología, Universidad Autónoma de Entre Ríos, E3202 Paraná, Entre Ríos, Argentina

8. Grupo de Análisis de Neuroimágenes, Instituo de Matemática Aplicada del Litoral, S3000 Santa Fe, Argentina

9. School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, 1010 Auckland, New Zealand

10. Neuropsychopharmacology Unit, Centre for Psychiatry, Imperial College London, London SW7 2AZ, United Kingdom

11. Centre for Psychedelic Research, Department of Psychiatry, Imperial College London, London SW7 2AZ, United Kingdom

12. Department of Neurological Surgery, University of California, Irvine, CA 92697

13. Brain Injury Research Center, Department of Neurosurgery, University of California, Los Angeles, CA 90095

14. Redwood Center for Theoretical Neuroscience, University of California, Berkeley, CA 94704

Abstract

Significance What changes in the brain when we lose consciousness? One possibility is that the loss of consciousness corresponds to a transition of the brain’s electric activity away from edge-of-chaos criticality, or the knife’s edge in between stability and chaos. Recent mathematical developments have produced tools for testing this hypothesis, which we apply to cortical recordings from diverse brain states. We show that the electric activity of the cortex is indeed poised near the boundary between stability and chaos during conscious states and transitions away from this boundary during unconsciousness and that this transition disrupts cortical information processing.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference124 articles.

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