Epigenetic state determines inflammatory sensing in neuroblastoma-Reference-Cited by-同舟云学术

Epigenetic state determines inflammatory sensing in neuroblastoma

Published:2022-02-04 Issue:6 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Wolpaw Adam J.¹²³^ORCID,Grossmann Liron D.¹²,Dessau Jessica L.³^ORCID,Dong May M.³^ORCID,Aaron Bailey J.³,Brafford Patricia A.³^ORCID,Volgina Darya³^ORCID,Pascual-Pasto Guillem¹²,Rodriguez-Garcia Alba⁴^ORCID,Uzun Yasin¹²⁵,Arsenian-Henriksson Marie⁶^ORCID,Powell Daniel J.⁴,Bosse Kristopher R.¹²⁷,Kossenkov Andrew⁸,Tan Kai¹²⁵⁷^ORCID,Hogarty Michael D.¹²⁷^ORCID,Maris John M.¹²⁷^ORCID,Dang Chi V.³⁹^ORCID

Affiliation:

1. Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104

2. Center for Childhood Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104

3. Molecular and Cellular Oncogenesis Program, Wistar Institute, Philadelphia, PA 19104

4. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104

5. Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104

6. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17165 , Sweden

7. Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104

8. Gene Expression and Regulation Program, Wistar Institute, Philadelphia, PA 19104

9. Ludwig Institute for Cancer Research, New York, NY 10017

Abstract

Significance Making immunotherapy more widely effective requires improved understanding of the pathways that regulate the interactions between tumor and immune cells. This work identified a previously unappreciated difference in these pathways between heterogenous epigenetic states that coexist in neuroblastoma. The generally rarer mesenchymal subpopulation has more active inflammatory sensing and signaling, revealing a potential immunologic vulnerability of these chemotherapy-resistant cells.

Funder

Alex''''s Lemonade Stand Foundation for Childhood Cancer

Hyundai Motor Group | Hyundai Motor America | Hyundai Hope On Wheels

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | National Cancer Institute

Solving Kids'''' Cancer

Ludwig Institute for Cancer Research

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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