The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies-Reference-Cited by-同舟云学术

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Published:2022-05-16 Issue:21 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Manry Jérémy¹²,Bastard Paul¹²³^ORCID,Gervais Adrian¹²,Le Voyer Tom¹²,Rosain Jérémie¹²^ORCID,Philippot Quentin¹²,Michailidis Eleftherios⁴^ORCID,Hoffmann Hans-Heinrich⁴,Eto Shohei⁵,Garcia-Prat Marina⁶,Bizien Lucy¹²,Parra-Martínez Alba⁶,Yang Rui³^ORCID,Haljasmägi Liis⁷,Migaud Mélanie¹²,Särekannu Karita⁷,Maslovskaja Julia⁷,de Prost Nicolas⁸⁹,Tandjaoui-Lambiotte Yacine¹⁰,Luyt Charles-Edouard¹¹¹²,Amador-Borrero Blanca¹³,Gaudet Alexandre¹⁴¹⁵,Poissy Julien¹⁴¹⁵,Morel Pascal¹⁶¹⁷,Richard Pascale¹⁶,Cognasse Fabrice¹⁸¹⁹,Troya Jesús²⁰^ORCID,Trouillet-Assant Sophie²¹²²²³,Belot Alexandre²¹²²²⁴²⁵,Saker Kahina²¹²²,Garçon Pierre²⁶,Rivière Jacques G.⁶,Lagier Jean-Christophe²⁷,Gentile Stéphanie²⁸²⁹,Rosen Lindsey B.³⁰,Shaw Elana³⁰,Morio Tomohiro³¹,Tanaka Junko³²,Dalmau David³³³⁴,Tharaux Pierre-Louis³⁵^ORCID,Sene Damien¹³,Stepanian Alain³⁶³⁷,Mégarbane Bruno³⁸,Triantafyllia Vasiliki³⁹,Fekkar Arnaud¹⁴⁰,Heath James R.⁴¹,Franco José Luis⁴²,Anaya Juan-Manuel⁴³,Solé-Violán Jordi⁴⁴⁴⁵⁴⁶,Imberti Luisa⁴⁷,Biondi Andrea⁴⁸,Bonfanti Paolo⁴⁹^ORCID,Castagnoli Riccardo³⁰⁵⁰,Delmonte Ottavia M.³⁰,Zhang Yu³⁰⁵¹,Snow Andrew L.⁵²^ORCID,Holland Steven M.³⁰,Biggs Catherine M.⁵³,Moncada-Vélez Marcela³,Arias Andrés Augusto³⁵⁴⁵⁵,Lorenzo Lazaro¹²,Boucherit Soraya¹²,Anglicheau Dany⁵⁶⁵⁷,Planas Anna M.⁵⁸⁵⁹^ORCID,Haerynck Filomeen⁶⁰,Duvlis Sotirija⁶¹⁶²,Ozcelik Tayfun⁶³,Keles Sevgi⁶⁴,Bousfiha Ahmed A.⁶⁵⁶⁶,El Bakkouri Jalila⁶⁵⁶⁶,Ramirez-Santana Carolina⁶⁷,Paul Stéphane⁶⁸^ORCID,Pan-Hammarström Qiang⁶⁹,Hammarström Lennart⁶⁹,Dupont Annabelle⁷⁰,Kurolap Alina⁷¹,Metz Christine N.⁷²,Aiuti Alessandro⁷³,Casari Giorgio⁷³,Lampasona Vito⁷⁴,Ciceri Fabio⁷⁵,Barreiros Lucila A.⁷⁶,Dominguez-Garrido Elena⁷⁷,Vidigal Mateus⁷⁸,Zatz Mayana⁷⁸,van de Beek Diederik⁷⁹,Sahanic Sabina⁸⁰,Tancevski Ivan⁸⁰,Stepanovskyy Yurii⁸¹,Boyarchuk Oksana⁸²,Nukui Yoko⁸³,Tsumura Miyuki⁵,Vidaur Loreto⁸⁴⁴⁵,Tangye Stuart G.⁸⁵⁸⁶,Burrel Sonia⁸⁷,Duffy Darragh⁸⁸^ORCID,Quintana-Murci Lluis⁸⁹⁹⁰,Klocperk Adam⁹¹,Kann Nelli Y.⁹²,Shcherbina Anna⁹²,Lau Yu-Lung⁹³,Leung Daniel⁹³,Coulongeat Matthieu⁹⁴,Marlet Julien⁹⁵⁹⁶^ORCID,Koning Rutger⁷⁹,Reyes Luis Felipe⁹⁷⁹⁸,Chauvineau-Grenier Angélique⁹⁹,Venet Fabienne¹⁰⁰¹⁰¹¹⁰²^ORCID,Monneret Guillaume¹⁰⁰¹⁰²,Nussenzweig Michel C.¹⁰³¹⁰⁴,Arrestier Romain⁸⁹,Boudhabhay Idris⁵⁶⁵⁷,Baris-Feldman Hagit⁷¹¹⁰⁵,Hagin David¹⁰⁵¹⁰⁶,Wauters Joost¹⁰⁷,Meyts Isabelle¹⁰⁸¹⁰⁹,Dyer Adam H.¹¹⁰¹¹¹^ORCID,Kennelly Sean P.¹¹⁰¹¹¹,Bourke Nollaig M.¹¹¹,Halwani Rabih¹¹²¹¹³,Sharif-Askari Fatemeh Saheb¹¹²,Dorgham Karim¹¹⁴,Sallette Jérôme¹¹⁵,Sedkaoui Souad Mehlal¹¹⁵,AlKhater Suzan¹¹⁶¹¹⁷,Rigo-Bonnin Raúl¹¹⁸,Morandeira Francisco¹¹⁹,Roussel Lucie¹²⁰¹²¹,Vinh Donald C.¹²⁰¹²¹,Erikstrup Christian¹²²,Condino-Neto Antonio⁷⁶^ORCID,Prando Carolina¹²³,Bondarenko Anastasiia⁸¹,Spaan András N.³¹²⁴,Gilardin Laurent¹²⁵¹²⁶,Fellay Jacques¹²⁷¹²⁸¹²⁹^ORCID,Lyonnet Stanislas¹³⁰,Bilguvar Kaya¹³¹¹³²¹³³¹³⁴,Lifton Richard P.⁵⁸¹³¹¹³²,Mane Shrikant¹³²,Anderson Mark S.⁵⁹,Boisson Bertrand¹²³^ORCID,Béziat Vivien¹²³^ORCID,Zhang Shen-Ying¹²³,Andreakos Evangelos³⁹,Hermine Olivier²⁶⁰,Pujol Aurora¹³⁵¹³⁶¹³⁷,Peterson Pärt⁷,Mogensen Trine H.¹³⁸¹³⁹,Rowen Lee⁴¹,Mond James¹⁴⁰,Debette Stéphanie¹⁴¹¹⁴²,de Lamballerie Xavier¹⁴³,Burdet Charles¹⁴⁴¹⁴⁵¹⁴⁶,Bouadma Lila¹⁴⁵¹⁴⁷,Zins Marie¹⁴⁸,Soler-Palacin Pere⁶,Colobran Roger¹⁴⁹,Gorochov Guy¹¹⁴¹⁵⁰^ORCID,Solanich Xavier¹⁵¹^ORCID,Susen Sophie⁷⁰,Martinez-Picado Javier¹⁵²¹⁵³¹⁵⁴¹³⁷¹⁵⁵^ORCID,Raoult Didier²⁷,Vasse Marc¹⁵⁶,Gregersen Peter K.⁷²,Piemonti Lorenzo⁷⁴,Rodríguez-Gallego Carlos⁴⁶¹⁵⁷,Notarangelo Luigi D.³⁰,Su Helen C.³⁰¹⁵⁸,Kisand Kai⁷,Okada Satoshi⁵,Puel Anne¹²³^ORCID,Jouanguy Emmanuelle¹²³,Rice Charles M.⁴^ORCID,Tiberghien Pierre¹⁶¹⁷,Zhang Qian¹²³^ORCID,Casanova Jean-Laurent¹²³¹⁰⁴^ORCID,Abel Laurent¹²³,Cobat Aurélie¹²³^ORCID,Zhang Peng,Seeleuthner Yoann,Talouarn Estelle,Marchal Astrid,Matuozzo Daniela,de la Chapelle Aliénor,Chen Jie,Chrabieh Maya,Liu Dana,Nemirowskaya Yelena,Cruz Inés Marín,Materna Marie,Pelet Sophie,Thibault Chloé,Liu Zhiyong,Abad Jorge,Accordino Giulia,Achille Cristian,Aguilera-Albesa Sergio,Aguiló-Cucurull Aina,Aiuti Alessandro,Özkan Esra Akyüz,Darazam Ilad Alavi,Albisures Jonathan Antonio Roblero,Aldave Juan C.,Ramos Miquel Alfonso,Khan Taj Ali,Aliberti Anna,Nadji Seyed Alireza,Alkan Gulsum,AlKhater Suzan A.,Allardet-Servent Jerome,Allende Luis M.,Alonso-Arias Rebeca,Alshahrani Mohammed S.,Alsina Laia,Alyanakian Marie-Alexandra,Borrero Blanca Amador,Amoura Zahir,Antolí Arnau,Arrestier Romain,Aubart Mélodie,Auguet Teresa,Avramenko Iryna,Aytekin Gökhan,Azot Axelle,Bahram Seiamak,Bajolle Fanny,Baldanti Fausto,Baldolli Aurélie,Ballester Maite,Feldman Hagit Baris,Barrou Benoit,Barzaghi Federica,Basso Sabrina,Bayhan Gulsum Iclal,Belot Alexandre,Bezrodnik Liliana,Bilbao Agurtzane,Blanchard-Rohner Geraldine,Blanco Ignacio,Blandinières Adeline,Blázquez-Gamero Daniel,Bleibtreu Alexandre,Bloomfield Marketa,Bolivar-Prados Mireia,Bondarenko Anastasiia,Borghesi Alessandro,Borie Raphael,Botdhlo-Nevers Elisabeth,Bousfiha Ahmed A.,Bousquet Aurore,Boutolleau David,Bouvattier Claire,Boyarchuk Oksana,Bravais Juliette,Briones M. Luisa,Brunner Marie-Eve,Bruno Raffaele,Bueno Maria Rita P.,Bukhari Huda,Bustamante Jacinta,Agra Juan José Cáceres,Capra Ruggero,Carapito Raphael,Carrabba Maria,Casari Giorgio,Casasnovas Carlos,Caseris Marion,Cassaniti Irene,Castelle Martin,Castelli Francesco,de Vera Martín Castillo,Castro Mateus V.,Catherinot Emilie,Celik Jale Bengi,Ceschi Alessandro,Chalumeau Martin,Charbit Bruno,Cheng Matthew P.,Clavé Pere,Clotet Bonaventura,Codina Anna,Cohen Yves,Colobran Roger,Comarmond Cloé,Combes Alain,Comoli Patrizia,Corsico Angelo G.,Coşkuner Taner,Cvetkovski Aleksandar,Cyrus Cyril,Dalmau David,Danion François,Darley David Ross,Das Vincent,Dauby Nicolas,Dauger Stéphane,De Munter Paul,de Pontual Loic,Dehban Amin,Delplancq Geoffroy,Demoule Alexandre,Desguerre Isabelle,Di Sabatino Antonio,Diehl Jean-Luc,Dobbelaere Stephanie,Domínguez-Garrido Elena,Dubost Clément,Ekwall Olov,Bozdemir Şefika Elmas,Elnagdy Marwa H.,Emiroglu Melike,Endo Akifumi,Erdeniz Emine Hafize,Aytekin Selma Erol,Lasa Maria Pilar Etxart,Euvrard Romain,Fabio Giovanna,Faivre Laurence,Falck Antonin,Fartoukh Muriel,Faure Morgane,Arquero Miguel Fernandez,Ferrer Ricard,Ferreres Jose,Flores Carlos,Francois Bruno,Fumadó Victoria,Fung Kitty S. C.,Fusco Francesca,Gagro Alenka,Solis Blanca Garcia,Gaussem Pascale,Gayretli Zeynep,Gil-Herrera Juana,Gilardin Laurent,Gatineau Audrey Giraud,Girona-Alarcón Mònica,Godínez Karen Alejandra Cifuentes,Goffard Jean-Christophe,Gonzales Nacho,Gonzalez-Granado Luis I.,González-Montelongo Rafaela,Guerder Antoine,Gülhan Belgin,Gumucio Victor Daniel,Hanitsch Leif Gunnar,Gunst Jan,Gut Marta,Hadjadj Jérôme,Haerynck Filomeen,Halwani Rabih,Hammarström Lennart,HANCERLI Selda,Hariyan Tetyana,Hatipoglu Nevin,Heppekcan Deniz,Hernandez-Brito Elisa,Ho Po-ki,Holanda-Peña María Soledad,Horcajada Juan P.,Hraiech Sami,Humbert Linda,Hung Ivan F. N.,Iglesias Alejandro D.,Íñigo-Campos Antonio,Jamme Matthieu,Arranz María Jesús,Jimeno Marie-Thérèse,Jordan Iolanda,Kanık-Yüksek Saliha,Kara Yalcin Burak,Karahan Aydın,Karbuz Adem,Yasar Kadriye Kart,Kasapcopur Ozgur,Kashimada Kenichi,Keles Sevgi,Demirkol Yasemin Kendir,Kido Yasutoshi,Kizil Can,Kılıç Ahmet Osman,Klocperk Adam,Daganou Maria,Koukaki Evangelia,Koutsoukou Antonia,Rapti Vasiliki,Syrigos Konstantinos,Król Zbigniew J.,Ksouri Hatem,Kuentz Paul,Kwan Arthur M. C.,Kwan Yat Wah M.,Kwok Janette S. Y.,Lagier Jean-Christophe,Lam David S. Y.,Conti Francesca,Pession Andrea,Lampropoulou Vicky,Lanternier Fanny,Lau Yu-Lung,Bourgeois Fleur Le,Leo Yee-Sin,Lopez Rafael Leon,Leung Daniel,Levin Michael,Levy Michael,Lévy Romain,Li Zhi,Lilleri Daniele,Lima Edson Jose Adrian Bolanos,Linglart Agnes,López-Collazo Eduardo,Lorenzo-Salazar José M.,Louapre Céline,Lubetzki Catherine,Lung Kwok-Cheung,Luyt Charles-Edouard,Lye David C.,Magnone Cinthia,Mansouri Davood,Marchioni Enrico,Marioli Carola,Marjani Majid,Marques Laura,Pereira Jesus Marquez,Martín-Nalda Andrea,Pueyo David Martínez,Martinez-Picado Javier,Marzana Iciar,Mata-Martínez Carmen,Mathian Alexis,Matos Larissa RB,Matthews Gail V.,Mayaux Julien,McLaughlin-Garcia Raquel,Meersseman Philippe,Mège Jean-Louis,Mekontso-Dessap Armand,Melki Isabelle,Meloni Federica,Meritet Jean-François,Merlani Paolo,Akcan Özge Metin,Meyts Isabelle,Mezidi Mehdi,Migeotte Isabelle,Millereux Maude,Million Matthieu,Mirault Tristan,Mircher Clotilde,Mirsaeidi Mehdi,Mizoguchi Yoko,Modi Bhavi P.,Mojoli Francesco,Moncomble Elsa,Melián Abián Montesdeoca,Martinez Antonio Morales,Morandeira Francisco,Morange Pierre-Emmanuel,Mordacq Clémence,Morelle Guillaume,Mouly Stéphane J.,Muñoz-Barrera Adrián,Nafati Cyril,Nagashima Shintaro,Nakagama Yu,Neven Bénédicte,Neves João Farela,Ng Lisa F. P.,Ng Yuk-Yung,Nielly Hubert,Medina Yeray Novoa,Cuadros Esmeralda Nuñez,Ocejo-Vinyals J. Gonzalo,Okamoto Keisuke,Oualha Mehdi,Ouedrani Amani,Özçelik Tayfun,Ozkaya-Parlakay Aslinur,Pagani Michele,Pan-Hammarström Qiang,Papadaki Maria,Parizot Christophe,Parola Philippe,Pascreau Tiffany,Paul Stéphane,Paz-Artal Estela,Pedraza-Sánchez Sigifredo,Gálvez-Romero José Luis,Pellecer Nancy Carolina González,Pellegrini Silvia,Diego Rebeca Pérez de,Pérez-Fernández Xosé Luis,Philippe Aurélien,Philippot Quentin,Picod Adrien,de Chambrun Marc Pineton,Piralla Antonio,Planas-Serra Laura,Ploin Dominique,Poissy Julien,Poncelet Géraldine,Poulakou Garyphallia,Pouletty Marie S.,Pourshahnazari Persia,Qiu-Chen Jia Li,Quentric Paul,Rambaud Thomas,Raoult Didier,Raoult Violette,Rebillat Anne-Sophie,Redin Claire,Resmini Léa,Ricart Pilar,Richard Jean-Christophe,Rigo-Bonnin Raúl,rivet Nadia,Rivière Jacques G.,Rocamora-Blanch Gemma,Rodero Mathieu P.,Rodrigo Carlos,Rodriguez Luis Antonio,Rodriguez-Gallego Carlos,Rodriguez-Palmero Agustí,Romero Carolina Soledad,Rothenbuhler Anya,Roux Damien,Rovina Nikoletta,Rozenberg Flore,Ruch Yvon,Ruiz Montse,Prado Maria Yolanda Ruiz del,Ruiz-Rodriguez Juan Carlos,Sabater-Riera Joan,Saks Kai,Salagianni Maria,Sanchez Oliver,Sánchez-Montalvá Adrián,Sánchez-Ramón Silvia,Schidlowski Laire,Schluter Agatha,Schmidt Julien,Schmidt Matthieu,Schuetz Catharina,Schweitzer Cyril E.,Scolari Francesco,Sediva Anna,Seijo Luis,Seminario Analia Gisela,Sene Damien,Seng Piseth,Senoglu Sevtap,Seppänen Mikko,Llovich Alex Serra,Shahrooei Mohammad,Shcherbina Anna,Siguret Virginie,Siouti Eleni,Smadja David M.,Smith Nikaia,Sobh Ali,Solanich Xavier,Solé-Violán Jordi,Soler Catherine,Soler-Palacín Pere,Sözeri Betül,Stella Giulia Maria,Stepanovskiy Yuriy,Stoclin Annabelle,Taccone Fabio,Tandjaoui-Lambiotte Yacine,Taupin Jean-Luc,Tavernier Simon J.,Vidaur Loreto,Terrier Benjamin,Thiery Guillaume,Thorball Christian,Thorn Karolina,Thumerelle Caroline,Tipu Imran,Tolstrup Martin,Tomasoni Gabriele,Toubiana Julie,Alvarez Josep Trenado,Trouillet-Assant Sophie,Troya Jesús,Tsang Owen T. Y.,Tserel Liina,Tso Eugene Y. K.,Tucci Alessandra,Öz Şadiye Kübra Tüter,Ursini Matilde Valeria,Utsumi Takanori,Uzunhan Yurdagul,Vabres Pierre,Valencia-Ramos Juan,Van Den Rym Ana Maria,Vandernoot Isabelle,Velez-Santamaria Valentina,Veliz Silvia Patricia Zuniga,Vidigal Mateus C.,Viel Sébastien,Villain Cédric,Vilaire-Meunier Marie E.,Villar-García Judit,Vincent Audrey,Vogt Guillaume,Voiriot Guillaume,Volokha Alla,Vuotto Fanny,Wauters Els,Wauters Joost,Wu Alan K. L.,Wu Tak-Chiu,Yahşi Aysun,Yesilbas Osman,Yildiz Mehmet,Young Barnaby E.,Yükselmiş Ufuk,Zatz Mayana,Ghirardello Stefano,Zuccaro Valentina,Andrés Ana de,Van Praet Jens,Lambrecht Bart N.,Van Braeckel Eva,Bosteels Cédric,Hoste Levi,Hoste Eric,Bauters Fré,Clercq Jozefien De,Heijmans Cathérine,Slabbynck Hans,Naesens Leslie,Florkin Benoit,Boulanger Cécile,Vanderlinden Dimitri,Foti Giuseppe,Bellani Giacomo,Citerio Giuseppe,Contro Ernesto,Pesci Alberto,Valsecchi Maria Grazia,Cazzaniga Marina,Danielson Jeffrey J.,Dobbs Kerry,Kashyap Anuj,Ding Li,Dalgard Clifton L.,Sottini Alessandra,Quaresima Virginia,Quiros-Roldan Eugenia,Rossi Camillo,Bettini Laura Rachele,D’Angio Mariella,Beretta Ilaria,Montagna Daniela,Licari Amelia,Marseglia Gian Luigi,Batten Isabella,Reddy Conor,McElheron Matt,Noonan Claire,Connolly Emma,Fallon Aoife,Storgaard Merete,Jørgensen Sofie,Tolstrup Martin,Erikstrup Christian,Pedersen Ole Birger,Sørensen Erik,Mikkelsen Susan,Dinh Khoa Manh,Larsen Margit Anita Hørup,Paulsen Isabella Worlewenut,Von Stemann Jakob Hjorth,Hansen Morten Bagge,Ostrowski Sisse Rye,Townsend Liam,Ni Cheallaigh Cliona,Bergin Colm,Martin-Loeches Ignacio,Dunne Jean,Conlon Niall,Bourke Nollaig,O’Farrelly Cliona,Abel Laurent,Allavena Clotilde,Andrejak Claire,Angoulvant François,Azoulay Cecile,Bachelet Delphine,Bartoli Marie,Basmaci Romain,Behillill Sylvie,Beluze Marine,Benech Nicolas,Benkerrou Dehbia,Bhavsar Krishna,Bitker Laurent,Bouadma Lila,Bouscambert-Duchamp Maude,Paz Pauline Caraux,Cervantes-Gonzalez Minerva,Chair Anissa,Chirouze Catherine,Coelho Alexandra,Cordel Hugues,Couffignal Camille,Couffin-Cadiergues Sandrine,d’Ortenzio Eric,De Montmollin Etienne,Debard Alexa,Debray Marie-Pierre,Deplanque Dominique,Descamps Diane,Desvallée Mathilde,Diallo Alpha,Diehl Jean-Luc,Diouf Alphonsine,Dorival Céline,Dubos François,Duval Xavier,Eloy Philippine,Enouf Vincent,Epaulard Olivier,Esperou Hélène,Esposito-Farase Marina,Etienne Manuel,Garot Denis,Gault Nathalie,Gaymard Alexandre,Ghosn Jade,Gigante Tristan,Gilg Morgane,Goehringer François,Guedj Jérémie,Hoctin Alexandre,Hoffmann Isabelle,Houas Ikram,Hulot Jean-Sébastien,Jaafoura Salma,Kafif Ouifiya,Kaguelidou Florentia,Kali Sabrina,Kerroumi Younes,Khalil Antoine,Khan Coralie,Kimmoun Antoine,Laine Fabrice,Laouénan Cédric,Laribi Samira,Le Minh,Le Bris Cyril,Le Gac Sylvie,Le Hingrat Quentin,Le Mestre Soizic,Le Nagard Hervé,Lemaignen Adrien,Lemee Véronique,Lescure François-Xavier,Letrou Sophie,Levy Yves,Lina Bruno,Lingas Guillaume,Lucet Jean Christophe,Machado Moïse,Malvy Denis,Mambert Marina,Manuel Aldric,Mentré France,Meziane Amina,Mouquet Hugo,Mullaert Jimmy,Neant Nadège,Nguyen Duc,Noret Marion,Papadopoulos Aurélie,Paul Christelle,Peiffer-Smadja Nathan,Peigne Vincent,Petrov-Sanchez Ventzislava,Peytavin Gilles,Pham Huong,Picone Olivier,Piquard Valentine,Poissy Julien,Puéchal Oriane,Rosa-Calatrava Manuel,Rossignol Bénédicte,Rossignol Patrick,Roy Carine,Schneider Marion,Su Richa,Tardivon Coralie,Tellier Marie-Capucine,Téoulé François,Terrier Olivier,Timsit Jean-François,Tual Christelle,Tubiana Sarah,Van Der Werf Sylvie,Vanel Noémie,Veislinger Aurélie,Visseaux Benoit,Wiedemann Aurélie,Yazdanpanah Yazdan,Annereau Jean-Philippe,Briseño-Roa Luis,Gribouval Olivier,Jaïs Jean-Philippe,Pelet Anna,Abel Laurent,Alcover Andres,Aschard Hugues,Bousso Philippe,Bourke Nollaig,Brodin Petter,Bruhns Pierre,Cerf-Bensussan Nadine,Cumano Ana,D’Enfert Christophe,Deriano Ludovic,Dillies Marie-Agnès,Di Santo James,Dromer Françoise,Eberl Gérard,Enninga Jost,Fellay Jacques,Gomperts-Boneca Ivo,Hasan Milena,Hedestam Gunilla Karlsson,Hercberg Serge,Ingersoll Molly A.,Lantz Olivier,Kenny Rose Anne,Ménager Mickaël,Michel Frédérique,Mouquet Hugo,O’Farrelly Cliona,Patin Etienne,Pellegrini Sandra,Rausell Antonio,Rieux-Laucat Frédéric,Rogge Lars,Fontes Magnus,Sakuntabhai Anavaj,Schwartz Olivier,Schwikowski Benno,Shorte Spencer,Tangy Frédéric,Toubert Antoine,Touvier Mathilde,Ungeheuer Marie-Noëlle,Zimmer Christophe,Albert Matthew L.,Duffy Darragh,Quintana-Murci Lluis,Alavoine Loubna,Behillil Sylvie,Burdet Charles,Charpentier Charlotte,Dechanet Aline,Descamps Diane,Duval Xavier,Ecobichon Jean-Luc,Enouf Vincent,Frezouls Wahiba,Houhou Nadhira,Kafif Ouifiya,Lehacaut Jonathan,Letrou Sophie,Lina Bruno,Lucet Jean-Christophe,Manchon Pauline,Nouroudine Mariama,Piquard Valentine,Quintin Caroline,Thy Michael,Tubiana Sarah,van der Werf Sylvie,Vignali Valérie,Visseaux Benoit,Yazdanpanah Yazdan,Chahine Abir,Waucquier Nawal,Migaud Maria-Claire,Deplanque Dominique,Djossou Félix,Mergeay-Fabre Mayka,Lucarelli Aude,Demar Magalie,Bruneau Léa,Gérardin Patrick,Maillot Adrien,Payet Christine,Laviolle Bruno,Laine Fabrice,Paris Christophe,Desille-Dugast Mireille,Fouchard Julie,Malvy Denis,Nguyen Duc,Pistone Thierry,Perreau Pauline,Gissot Valérie,Le Goas Carole,Montagne Samatha,Richard Lucie,Chirouze Catherine,Bouiller Kévin,Desmarets Maxime,Meunier Alexandre,Bourgeon Marilou,Lefèvre Benjamin,Jeulin Hélène,Legrand Karine,Lomazzi Sandra,Tardy Bernard,Gagneux-Brunon Amandine,Bertholon Frédérique,Botelho-Nevers Elisabeth,Kouakam Christelle,Leturque Nicolas,Roufai Layidé,Amat Karine,Couffin-Cadiergues Sandrine,Espérou Hélène,Hendou Samia,van Agtmael Michiel,Algera Anne Geke,Appelman Brent,van Baarle Frank,Bax Diane,Beudel Martijn,Bogaard Harm Jan,Bomers Marije,Bonta Peter,Bos Lieuwe,Botta Michela,de Brabander Justin,de Bree Godelieve,de Bruin Sanne,Buis David T. P.,Bugiani Marianna,Bulle Esther,Chouchane Osoul,Cloherty Alex,Dijkstra Mirjam,Dongelmans Dave A.,Dujardin Romein W. G.,Elbers Paul,Fleuren Lucas,Geerlings Suzanne,Geijtenbeek Theo,Girbes Armand,Goorhuis Bram,Grobusch Martin P.,Hafkamp Florianne,Hagens Laura,Hamann Jorg,Harris Vanessa,Hemke Robert,Hermans Sabine M.,Heunks Leo,Hollmann Markus,Horn Janneke,Hovius Joppe W.,de Jong Menno D.,Koning Rutger,Lim Endry H. T.,van Mourik Niels,Nellen Jeaninne,Nossent Esther J.,Paulus Frederique,Peters Edgar,Pina-Fuentes Dan A. I.,van der Poll Tom,Preckel Bennedikt,Prins Jan M.,Raasveld Jorinde,Reijnders Tom,de Rotte Maurits C. F. J.,Schinkel Michiel,Schultz Marcus J.,Schrauwen Femke A. P.,Schuurman Alex,Schuurmans Jaap,Sigaloff Kim,Slim Marleen A.,Smeele Patrick,Smit Marry,Stijnis Cornelis S.,Stilma Willemke,Teunissen Charlotte,Thoral Patrick,Tsonas Anissa M.,Tuinman Pieter R.,van der Valk Marc,Veelo Denise,Volleman Carolien,de Vries Heder,Vught Lonneke A.,van Vugt Michèle,Wouters Dorien,Zwinderman A. H. (Koos),Brouwer Matthijs C.,Wiersinga W. Joost,Vlaar Alexander P. J.,van de Beek Diederik,Abel Laurent,Aiuti Alessandro,Al-Muhsen Saleh,Al-Mulla Fahd,Anderson Mark S.,Andreakos Evangelos,Arias Andrés A.,Feldman Hagit Baris,Belot Alexandre,Biggs Catherine M.,Bogunovic Dusan,Bolze Alexandre,Bondarenko Anastasiia,Bousfiha Ahmed A.,Brodin Petter,Bryceson Yenan,Bustamante Carlos D.,Butte Manish J.,Casari Giorgio,Chakravorty Samya,Christodoulou John,Condino-Neto Antonio,Constantinescu Stefan N.,Cooper Megan A.,Dalgard Clifton L.,Desai Murkesh,Drolet Beth A.,El Baghdadi Jamila,Espinosa-Padilla Sara,Fellay Jacques,Flores Carlos,Franco José Luis,Froidure Antoine,Gregersen Peter K.,Haerynck Filomeen,Hagin David,Halwani Rabih,Hammarström Lennart,Heath James R.,Henrickson Sarah E.,Hsieh Elena W. Y.,Husebye Eystein S.,Imai Kohsuke,Itan Yuval,Jarvis Erich D.,Karamitros Timokratis,Kisand Kai,Ku Cheng-Lung,Lau Yu-Lung,Ling Yun,Lucas Carrie L.,Maniatis Tom,Mansouri Davood,Maródi László,Meyts Isabelle,Milner Joshua D.,Mironska Kristina,Mogensen Trine H.,Morio Tomohiro,Ng Lisa F. P.,Notarangelo Luigi D.,Novelli Antonio,Novelli Giuseppe,O’Farrelly Cliona,Okada Satoshi,Ozcelik Tayfun,Pan-Hammarström Qiang,de Diego Rebeca Perez,Planas Anna M.,Perez-Tur Jordi,Arkin Lisa M.,Asano Takaki,Oriol Roger Colobran,Prando Carolina,Pujol Aurora,Quintana-Murci Lluis,Renia Laurent,Resnick Igor,Rodríguez-Gallego Carlos,Sancho-Shimizu Vanessa,Sediva Anna,Seppänen Mikko R.J.,Shahrooei Mohammed,Shcherbina Anna,Slaby Ondrej,Snow Andrew L.,Soler-Palacín Pere,Spaan András N.,Tancevski Ivan,Tangye Stuart G.,Tayoun Ahmad Abou,Ramaswamy Sathishkumar,Turvey Stuart E.,Uddin K. M. Furkan,Uddin Mohammed J.,van de Beek Diederik,Vinh Donald C.,von Bernuth Horst,Zatz Mayana,Zawadzki Pawel,Grimbacher Bodo,Okamoto Keisuke,Pape Jean W.,Perlin David S.,Pesole Graziano,Wauters Joost,Su Helen C.,Casanova Jean-Laurent,García Paula Andrea Gaviria,López Gustavo Andrés Salguero,Rojas-Villaraga Adriana,Vélez Verónica Posada,Landinez Lina Marcela Acevedo,Correales Luisa Paola Duarte,Gómez Oscar,Guaqueta Jeser Santiago Grass,Pérez Cristian Alejandro Ricaurte,Carrillo Jorge,Vergara José Alejandro Daza,Landinez Sandra,Mantilla Rubén D.,Yepes Jairo David Torres,Ricaurte Oscar Andrés Briceño,Pérez-Díaz Carlos E.,Mateus Yady Nataly,Navarro Laura Mancera,Rodríguez Yhojan,Acosta-Ampudia Yeny,Monsalve Diana M.,Rojas Manuel,Nadif Rachel,Goldberg Marcel,Ozguler Anna,Henny Joseph,Lemonnier Sylvie,Coeuret-Pellicer Mireille,Got Stéphane Le,Zins Marie,Tzourio Christophe,Debette Stéphanie,Dufouil Carole,Soumaré Aïcha,Lachaize Morgane,Fievet Nathalie,Flaig Amandine,Martin Fernando,Bonneaudeau Brigitte,Cognasse Fabrice,Cannet Dorothée,Gallian Pierre,Jeanne Michel,Morel Pascal,Perroquin Magali,Richard Pascale,Tiberghien Pierre,Hamzeh-Cognasse Hind, , , , , , , , , , , , , , , , , , ,

Affiliation:

1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France

2. Imagine Institute, University of Paris, 75015 Paris, France

3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065

4. Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065

5. Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan

6. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain

7. Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia

8. Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France

9. Groupe de Recherche Clinique Cardiovascular and Respiratory Manifestations of Acute Lung Injury and Sepsis (CARMAS), Faculté de santé de Créteil, Université Paris Est Créteil, 94010 Créteil Cedex, France

10. Hypoxia and Lung, INSERM U1272, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, 93022 Bobigny, France

11. Sorbonne Université, Hôpital Pitié Salpêtrière, Médecine Intensive Réanimation, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France

12. INSERM, UMRS 1166-iCAN, Institute of Cardiometabolism and Nutrition, 75013 Paris, France

13. Internal Medicine Department, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, 75010 Paris, France

14. INSERM U1019–CNRS UMR9017, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, University of Lille, 59000 Lille, France

15. Centre Hospitalier Universitaire, de Lille, Pôle de Réanimation, Hôpital Roger Salengro Lille, 59000 Lille, France

16. Etablissement Français du Sang, 93218 La Plaine Saint-Denis, France

17. Interactions Hôte-Greffon-Tumeur et Ingénierie Cellulaire et Génique (RIGHT), INSERM, Etablissement Français du Sang, Université de Franche-Comté, 25000 Besançon, France

18. Santé Ingéniérie Biologie St-Etienne (SAINBIOSE), INSERM U1059, University of Lyon, Université Jean Monnet Saint-Etienne, 42000 Saint-Étienne, France

19. Etablissement Français du Sang, Auvergne-Rhône-Alpes, 42000 Saint-Étienne, France

20. Department of Internal Medicine, Infanta Leonor University Hospital, 28031 Madrid, Spain

21. Hospices Civils de Lyon, 69002 Lyon, France

22. International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, Ecole Nationale Supérieure, Université Claude Bernard Lyon 1 (UCBL), 69365 Lyon, France

23. Joint Research Unit, Hospices Civils de Lyon-BioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre-Bénite, France

24. National Referee Centre for Rheumatic, and Autoimmune and Systemic Diseases in Children, 69000 Lyon, France

25. Immunopathology Federation Lyon Immunopathology Federation (LIFE), Hospices Civils de Lyon, 69002 Lyon, France

26. Intensive Care Unit, Grand Hôpital de l’Est Francilien Site de Marne-La-Vallée, 77600 Jossigny, France

27. Microbes, Evolution, Phylogénie et Infection (MEPHI), Institut Hospitalo-Universitaire Méditerranée Infection, Institut de Recherche pour le Développement, Assistance Publique Hôpitaux de Marseille, Aix-Marseille Université, 13005 Marseille, France

28. Service d’Evaluation Médicale, Hôpitaux Universitaires de Marseille Assistance Publique Hôpitaux de Marseille, 13005 Marseille, France

29. Aix-Marseille University, School of Medicine, EA 3279, Centre d'Études et de Recherche sur les Services de Santé et la Qualité de vie (CEReSS)–Health Service Research and Quality of Life Center, 13385 Marseille, France

30. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892

31. Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan

32. Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan

33. Hospital Universitari MútuaTerrassa, Universitat de Barcelona, 08193 Barcelona, Spain

34. Fundació Docència i Recerca Mutua Terrassa, 08221 Terrassa, Spain

35. Paris Cardiovascular Research Center (PARCC), INSERM, Université de Paris, 75015 Paris, France

36. Service d’Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Université de Paris, 75010 Paris, France

37. EA3518, Institut Universitaire d’Hématologie-Hôpital Saint Louis, Université de Paris, 75010 Paris, France

38. Réanimation Médicale et Toxicologique, Hôpital Lariboisière Assistance Publique-Hôpitaux de Paris, Université de Paris, INSERM, UMRS-1144, 75010 Paris, France

39. Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece

40. Service de Parasitologie-Mycologie, Groupe Hospitalier Pitié Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France

41. Institute for Systems Biology, Seattle, WA 98109

42. Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UdeA, 050010 Medellín, Colombia

43. Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 110111 Bogotá, Colombia

44. Intensive Care Medicine, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, 35010 Las Palmas de Gran Canaria, Spain

45. Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain

46. Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain

47. CHemato-oncology Research Laboratory of Associazione italiana contro le leucemie-linfomi e mieloma, Diagnostic Departement, Azienda Socio Sanitaria Territoriale, Spedali Civili di Brescia, 25123 Brescia, Italy

48. Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN), University of Milano Bicocca, Fondazione Monza Brianza Bambino Mamma (MBBM), Ospedale San Gerardo, 20900 Monza, Italy

49. Department of Infectious Diseases, San Gerardo Hospital, University of Milano Bicocca, 20900 Monza, Italy

50. Pediatric Clinic, Fondazione Istituto di Ricovero e Cura a carattere scientifico (IRCCS) Policlinico San Matteo, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy

51. National Institute of Allergy and Infectious Diseases (NIAID) Clinical Genomics Program, NIH, Bethesda, MD 20892

52. Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814

53. Department of Pediatrics, British Columbia Children’s Hospital, University of British Columbia, Vancouver, BC V6H 0B3, Canada

54. Primary Immunodeficiencies Group, University of Antioquia UdeA, 050010 Medellin, Colombia

55. School of Microbiology, University of Antioquia UdeA, 050010 Medellin, Colombia

56. Department of Nephrology and Transplantation, Necker University Hospital, Assistance Publique-Hôpitaux de Paris, 75743 Paris, France

57. Institut Necker Enfants Malades, INSERM U1151–CNRS UMR 8253, Université de Paris, 75015 Paris, France

58. Institute for Biomedical Research, Spanish National Research Council, 08036 Barcelona, Spain

59. Institut d’Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain

60. Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, 9000 Ghent, Belgium

61. Faculty of Medical Sciences, University “Goce Delchev,” Štip 2000, Republic of North Macedonia

62. Institute of Public Health of the Republic of North Macedonia, Skopje 1000, Republic of North Macedonia

63. Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey

64. Meram Faculty of Medicine, Necmettin Erbakan University, 42080 Konya, Turkey

65. Clinical Immunology Unit, Department of Pediatric Infectious Disease, Centre Hospitalier-Universitaire Ibn Roucshd, 20360 Casablanca, Morocco

66. Laboratoire d’Immunologie Clinique, Inflammation et Allergie (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, 20250 Casablanca, Morocco

67. Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, 111211 Bogotá, Colombia

68. Department of Immunology, CIC1408, Groupe sur l’Immunité des Muqueuses et des Agents Pathogènes (GIMAP) Centre International de Recherche en Infectiologie, INSERM U1111, University Hospital of Saint-Étienne, 42000 Saint-Étienne, France

69. Department of Biosciences and Nutrition, Karolinska Institutet, 171 77 Stockholm, Sweden

70. University of Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France

71. The Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel

72. Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030

73. Vita-Salute San Raffaele University, and Clinical Genomics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, 20132 Milan, Italy

74. Diabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy

75. Hematology and Bone Marrow Transplantation Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele University Vita-Salute San Raffaele, 20132 Milano, Italy

76. Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-060 São Paulo, Brazil

77. Fundación Rioja Salud, Centro de Investigación Biomédica de La Rioja, 26006 Logroño, Spain

78. University of São Paulo, 05508-060 São Paulo, Brazil

79. Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands

80. Department of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria

81. Shupyk National Healthcare University of Ukraine, 04112 Kyiv, Ukraine

82. Department of Children’s Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, 46022 Ternopil, Ukraine

83. Department of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University, Tokyo 113-8655, Japan

84. Intensive Care Medicine, Donostia University Hospital, Biodonostia Institute of Donostia, 20014 San Sebastián, Spain

85. Garvan Institute of Medical Research, Sydney, NWS 2010, Australia

86. St Vincent’s Clinical School, Faculty of Medicine and Health, University of New South Wales, Sydney, NWS 2010, Australia

87. Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Service de Virologie, 75013 Paris, France

88. Translational Immunology Unit, Institut Pasteur, Université Paris Cité, 75015 Paris, France

89. Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015 Paris, France

90. Department of Human Genomics and Evolution, Collège de France, 75231 Paris, France

91. Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, 150 06 Prague, Czech Republic

92. Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia 117997

93. Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong 999077, China

94. Division of Geriatric Medicine, Tours University Medical Center, 37044 Tours, France

95. INSERM U1259, Morphogenèse et Antigénicité du VIH et des Virus des Hépatites (MAVIVH), Université de Tours, 37044 Tours, France

96. Service de Bactériologie, Virologie et Hygiène Hospitalière, Centre Hospitalier Universitaire de Tours, 37044 Tours, France

97. Department of Microbiology, Universidad de La Sabana, 250001 Chía, Colombia

98. Department of Critical Care Medicine, Clínica Universidad de La Sabana, 250001 Chía, Colombia

99. Service de Biologie Médicale, Centre Hospitalier Intercommunal Robert Ballanger, 93600 Aulnay-sous-Bois, France

100. Laboratoire d’Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, 69437 Lyon, France

101. Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, 69007 Lyon, France

102. EA 7426, Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, BioMérieux, Hôpital Edouard Herriot, 69437 Lyon, France

103. Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065

104. HHMI, Rockefeller University, New York, NY 10065

105. Sackler Faculty of Medicine, Tel Aviv University, 6997801 Tel Aviv, Israel

106. Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center, 6423906 Tel Aviv, Israel

107. Medical Intensive Care Unit, University Hospitals Leuven, 3000 Leuven, Belgium

108. Laboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, 3000 Leuven, Belgium

109. Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, 3000 Leuven, Belgium

110. Department of Age-Related Healthcare, Tallaght University Hospital, Dublin D24 NR0A, Ireland

111. Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland

112. Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates

113. Immunology Research Lab, College of Medicine, King Saud University, 11362 Riyadh, Saudi Arabia

114. Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses, 75013 Paris, France

115. Cerba HealthCare, 92130 Issy-les-Moulineaux, France

116. Department of Pediatrics, King Fahad Hospital of the University, Al Khobar 34445, Saudi Arabia

117. College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia

118. Department of Clinical Laboratory, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain

119. Department of Immunology, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain

120. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC H4A 3J1, Canada

121. Infectious Disease Susceptibility Program, Research Institute of the McGill University Health Centre, Montréal, QC H4A 3J1, Canada

122. Department of Clinical Immunology, Aarhus University Hospital, 8000 Aarhus, Denmark

123. Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, 80250-200 Curitiba, Brazil

124. Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands

125. Service de Médecine Interne, Hôpital Universitaire Jean-Verdier, Assistance Publique-Hôpitaux de Paris, 93140 Bondy, France

126. INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France

127. School of Life Sciences, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

128. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland

129. Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland

130. Imagine Institute, Université de Paris, INSERM, UMR 1163, 75015 Paris, France

131. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06511

132. Department of Genetics, Yale University School of Medicine, New Haven, CT 06520

133. Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510

134. Department of Medical Genetics, Acibadem University School of Medicine, 34750 Istanbul, Turkey

135. Neurometabolic Diseases Laboratory, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain

136. Centre for Biomedical Research on Rare Diseases (CIBERER) U759, Instituto de Salud Carlos III, 28029 Madrid, Spain

137. Catalan Institution of Research and Advanced Studies (ICREA), 08010 Barcelona, Spain

138. Department of Infectious Diseases, Aarhus University Hospital, 8000 Aarhus, Denmark

139. Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark

140. ADMA Biologics Inc., Ramsey, NJ 07446

141. University of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France

142. Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, F-33000 Bordeaux, France

143. Institut Hospitalo-Universitaire Méditerranée Infection, Unité des Virus Émergents, Aix-Marseille University, Institut pour la Recherche et le Développment (IRD) 190, INSERM 1207, 13005 Marseille, France

144. Epidémiologie clinique du Centre d’Investigation Clinique (CIC-EP), INSERM CIC 1425, Hôpital Bichat, 75018 Paris, France

145. Université de Paris, Infection Antimicrobials Modelling Evolution (IAME), UMR 1137, INSERM, 75870 Paris, France

146. Département Epidémiologie, Biostatistiques et Recherche Clinique, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 75018 Paris, France

147. Service de Réanimation Médicale et des Maladies Infectieuses, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Nord Université de Paris, F-75018 Paris, France

148. Cohorte Constances Groupe Hospitalier Universitaire centre, Assistance Publique-Hôpitaux de Paris, Université de Paris, 94800 Villejuif, France

149. Immunology Division, Genetics Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain

150. Département d’Immunologie, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpétrière, 75015 Paris, France

151. Department of Internal Medicine, Hospital Universitari de Bellvitge, The Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain

152. IrsiCaixa AIDS Research Institute, 08916 Badalona, Spain

153. Institute for Health Science Research Germans Trias i Pujol (IGTP), 08916 Badalona, Spain

154. Department of Infectious Diseases and Immunity, University of Vic-Central University of Catalonia, 08500 Vic, Spain

155. Consorcio Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain

156. Service de Biologie Clinique and UMR-S 1176, Hôpital Foch, 92150 Suresnes, France

157. Department of Immunology, University Hospital of Gran Canaria Dr. Negrin, Canarian Health System, 35010 Las Palmas de Gran Canaria, Spain

158. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104

Abstract

Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2200413119

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