Invited Perspective: Uneven Progress Addressing Population Variability in Human Health Risk Assessment
Author:
Affiliation:
1. Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas, USA
2. Interdisciplinary Faculty of Toxicology, Texas A&M University, College Station, Texas, USA
Publisher
Environmental Health Perspectives
Link
https://ehp.niehs.nih.gov/doi/pdf/10.1289/EHP13461
Reference30 articles.
1. World Health Organization/International Programme on Chemical Safety (WHO/IPCS). 2005. Chemical-Specific Adjustment Factors for Interspecies Differences and Human Variability: Guidance Document for Use of Data in Dose/Concentration-Response Assessment. Geneva Switzerland: WHO/ICPS. https://apps.who.int/iris/handle/10665/43294 [accessed 21 August 2023].
2. Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance
3. WHO/IPCS. 2018. Guidance Document on Evaluating and Expressing Uncertainty in Hazard Characterization 2nd ed. Geneva Switzerland: WHO. https://apps.who.int/iris/handle/10665/259858 [accessed 21 August 2023].
4. Distributions for time, interspecies and intraspecies extrapolation for deriving occupational exposure limits
5. Human variability in glutathione-S-transferase activities, tissue distribution and major polymorphic variants: Meta-analysis and implication for chemical risk assessment
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