1. PBPK Model-Dennal Input tion coefficients and Michaelis-Menton
2. A
PBPK model is being developed for pre- metabolic constants (Km V ax) were deter
3. dicting in vivo blood and tissue concentra- mined by in vitro techniques. Predicted
4. tions of a chemical after topical exposure blood levels after three different topical
5. In vitro skin absorption and metabo- doses of benzoic acid agreed closely with in