1. cells were obtained. One of these clones down regulation of thrombospondin
2. was highly homologous to the throm- promoter in Ni transformed cells (13).
3. bospondin gene. Figure 8 shows the Since the Ni-transformed cells had an
4. mRNA expression of the throm- inactivated senescence gene and formed
5. bospondin gene in normal cells and the tumors in nude mice it is possible that