Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case–Control Study in Spain and Italy

Author:

Villanueva Cristina M.1234,Gracia-Lavedan Esther134,Bosetti Cristina5,Righi Elena6,Molina Antonio José47,Martín Vicente47,Boldo Elena489,Aragonés Nuria489,Perez-Gomez Beatriz489,Pollan Marina489,Acebo Ines Gomez101112,Altzibar Jone M.413,Zabala Ana Jiménez13,Ardanaz Eva414,Peiró Rosana412,Tardón Adonina415,Chirlaque Maria Dolores416,Tavani Alessandra5,Polesel Jerry17,Serraino Diego17,Pisa Federica1819,Castaño-Vinyals Gemma1234,Espinosa Ana1234,Espejo-Herrera Nadia123,Palau Margarita20,Moreno Victor42122,La Vecchia Carlo23,Aggazzotti Gabriella6,Nieuwenhuijsen Mark J1234,Kogevinas Manolis1234

Affiliation:

1. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain

2. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

3. Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain

4. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

5. Department of Epidemiology, IRCCS (Istituto di Ricerche Farmacologiche Mario Negri), Milan, Italy

6. Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

7. Department of Preventive Medicine and Public Health, University of León, León, Spain

8. Cancer and Environmental Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain

9. Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS (Instituto de Investigación Sanitaria) Puerta De Hierro, Madrid, Spain

10. Department of Preventive Medicine and Public Health, University of Cantabria, Santander, Spain

11. IDIVAL (Instituto de Investigación Sanitaria Valdecilla), Santander, Spain

12. Centre for Research in Public Health, Valencia, Spain

13. Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain

14. Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain

15. Oncology Institute IUOPA (Instituto Universitario de Oncología del Principado de Asturias), Universidad de Oviedo, Asturias, Spain

16. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca (Biomedical Research Institute of Murcia), Murcia, Spain

17. Unit of Epidemiology and Biostatistics, CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute, IRCCS, Aviano, Italy

18. Institute of Hygiene and Clinical Epidemiology, University Hospital of Udine, Udine, Italy

19. Department of Biological and Medical Sciences, University of Udine, Udine, Italy

20. General Division of Public Health, Quality and Innovation, Ministry of Health, Social Services and Equity, Madrid, Spain

21. Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

22. Department of Clinical Sciences, University of Barcelona, Barcelona, Spain

23. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference43 articles.

1. Changes in Blood Trihalomethane Concentrations Resulting From Differences in Water Quality and Water Use Activities

2. BOE (Diario oficial Boletín Oficial del Estado). 2003. Real Decreto 140/2003 de 7 de febrero por el que se establecen los criterios sanitarios de la calidad del agua de consumo humano [in Spanish]. BOE 45 7228–7245 https://www.boe.es/buscar/doc.php?id=BOE-A-2003-3596 [accessed 27 October 2015].

3. Bosman FT Hamilton SR Lambert R. 2014. Colorectal cancer. In: World Cancer Report 2014 . Stewart BW Wild CP eds. Lyon France International Agency for Research on Cancer 392-402.

4. Case control study of the geographic variability of exposure to disinfectant byproducts and risk for rectal cancer

5. Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

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