Genetically engineered V79 Chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide.

Author:

Doehmer J1,Seidel A1,Oesch F1,Glatt H R1

Affiliation:

1. Institute of Toxicology, University of Mainz, Federal Republic of Germany.

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference4 articles.

1. Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.

2. Dogra S. Doehmer J. Glatt H. R. Siegert P. Friedberg T. Seidel A. and Oesch F. Stable expression of rat P-4501A1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing. Mol. Pharmacol. in press.

3. Activation of N-acetoxy- and N-hydroxy-2-acetylaminofluorene to mutagenic and cytotoxic metabolites by V79 Chinese hamster cells;Glatt H. R.;Mutat. Res.,1985

4. Characteristics of the activation of cyclophosphamide to a mutagen by rat liver

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