Author:
Kameswaran Mohan,Al-Wadei Abdulla,Khurana Praful,Okafor B. C.
Abstract
AbstractAspergillosis is increasingly being recognised as a common fungal infection of the paranasal sinuses. Although the disease is almost endemic in neighbouring Sudan, there are few reported cases from the Kingdom of Saudi Arabia. We report four cases of sinus aspergillosis with involvement of the skull bases and/or intracranial spread; a condition we have termed rhinocerebral aspergillosis. Invasive aspergillosis in our subgroup of patients occurs in otherwise healthy patients with normal immune status, quite unlike most reported cases in the western literature. The causative agent in all our patients was identified as aspergillus flavus, similar to patients reported from Sudan. This is again at variance with the case reports from other geographical locations, where aspergillus fumigatus is the commonest causative agent. Saudi Arabia would appear to represent a distinct geographical enclave, together with Sudan, where rhinocerebral aspergillosis of the sinuses and skull base may be more common than has previously been realised.
Publisher
Cambridge University Press (CUP)
Subject
Otorhinolaryngology,General Medicine
Reference18 articles.
1. Primary paranasal aspergillus granuloma in Saudi Arabia;Dawlatly;Tropical Geographical Medicine,1988
2. Sino-orbital aspergillosis: report of a case and review of the literature;Zinemann;Minnesota Medicine,1972
3. Primary aspergilloma of paranasal sinuses in the Sudan. A review of seventeen cases
4. Sinus Aspergillosis and Allergic Fungal Sinusitis
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