An allele at the triose phosphate isomerase,Tpi-1locus on chromosome 6 recovered from feral mice

Abstract

SummaryAn animal with low erythrocyte triose phosphate isomerase (TPI) activity was found amongst mice trapped on a farm in Leicestershire. The low TPI activity was caused by the segregation of a single co-dominant gene which also affected theKmfor glyceraldehyde-3-phosphate and heat stability of the enzyme. We designate the geneTpi-1, the structural locus for TPI, with theaallele in the common inbred strains and theballele derived from the wild-caught mouse.Tpi-1was known to be on chromosome 6 by somatic cell techniques and, as shown in a preliminary report (Peters & Bulfield, 1984), we have confirmed and extended this finding using three chromosome-6 marker genes giving the order:Sig-28-Lc-11-Miwh-16-Tpi-1.