Author:
Mukherjee Asit B.,Luckett Deborah C.,Herrera Rene J.
Abstract
Summary5-azacytidine-treated human fibroblasts exhibit a significant decrease in the frequencies of Barr body+ cells as compared to nontreated cultures. This presumably indicates that 5-azacytidine can induce a change in the degree of condensation of the Barr body. It is suggested that the state of chromatin condensation of the Barr body may be related to the reactivation process by 5-azacytidine of gene loci in the inactive X.
Subject
Genetics,General Medicine
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