Author:
García-Hernández P.,Rodero M.,Gisbert-Criado R.,Puente P.,Pelayo V.,Andreu-Ballester J.C.,Cuéllar C.
Abstract
AbstractPreviously, anin vitroeffect was observed on the complement system not only of the excretory-secretory products but also of somatic antigens from L3Anisakis simplexlarvae. In the present work the effect of anti-A. simplexspecific antibodies on C3 and C4 levels in human sera was investigated. Up to 309 samples of sera were tested to determine levels of C3 and C4 and anti-A. simplexantibodies, including immunoglobulins IgG, IgM, IgA and IgE. Significant differences were observed between levels of C3 and C4 and all immunoglobulins except for IgE. In the case of immunoglobulins, the probability that an anti-A. simplexpositive subject has a C3 deficiency was 3.8 times higher than a subject without specific antibodies. In conclusion, an association between elevated levels of anti-A. simplexantibodies and C3 and C4 deficiency was demonstrated.
Publisher
Cambridge University Press (CUP)
Subject
Animal Science and Zoology,General Medicine,Parasitology
Cited by
2 articles.
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