Author:
CHARLESWORTH BRIAN,CHARLESWORTH DEBORAH
Abstract
Data on the effects of inbreeding on fitness components are reviewed in the light of population
genetic models of the possible genetic causes of inbreeding depression. Deleterious mutations
probably play a major role in causing inbreeding depression. Putting together the different kinds of
quantitative genetic data, it is difficult to account for the very large effects of inbreeding on fitness
in Drosophila and outcrossing plants without a significant contribution from variability maintained
by selection. Overdominant effects of alleles on fitness components seem not to be important in
most cases. Recessive or partially recessive deleterious effects of alleles, some maintained by
mutation pressure and some by balancing selection, thus seem to be the most important source of
inbreeding depression. Possible experimental approaches to resolving outstanding questions are
discussed.
Subject
Genetics,General Medicine
Cited by
589 articles.
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