Author:
CAHN-WEINER DEBORAH A.,SULLIVAN EDITH V.,SHEAR PAULA K.,FAMA ROSEMARY,LIM KELVIN O.,YESAVAGE JEROME A.,TINKLENBERG JARED R.,PFEFFERBAUM ADOLF
Abstract
The Clock Drawing Test (CDT) is widely used in
the assessment of dementia and is known to be sensitive
to the detection of deficits in neurodegenerative disorders
such as Alzheimer's disease (AD). CDT performance
is dependent not only on visuospatial and constructional
abilities, but also on conceptual and executive functioning;
therefore, it is likely to be mediated by multiple brain
regions. The purpose of the present study was to identify
component cognitive processes and regional cortical volumes
that contribute to CDT performance in AD. In 29 patients
with probable AD, CDT performance was significantly related
to right-, but not left-hemisphere, regional gray matter
volume. Specifically, CDT score correlated significantly
with the right anterior and posterior superior temporal
lobe volumes. CDT scores showed significant relationships
with tests of semantic knowledge, executive function, and
visuoconstruction, and receptive language. These results
suggest that in AD patients, CDT performance is attributable
to impairment in multiple cognitive domains but is related
specifically to regional volume loss of right temporal
cortex. (JINS, 1999, 5, 502–509.)
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Neurology (clinical),Clinical Psychology,General Neuroscience
Cited by
80 articles.
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