Author:
KRAMER JOEL H.,YAFFE KRISTINE,LENGENFELDER JEANNE,DELIS DEAN C.
Abstract
Age and gender effects on verbal episodic memory are well
established. However, the possibility of interactions between
age and gender has been raised by studies linking estrogen and
verbal memory performance, and by research suggesting gender
differences in age-related cortical atrophy. We evaluated whether
age by gender interactions in verbal memory were present. Subjects
within three years of the median age of menopause were excluded
from a large cohort of normal subjects, resulting in a younger
sample (16–47 years) of 288 men and 285 women, and an
older sample (55–89 years) of 201 men and 245 women. All
subjects were administered the CVLT-2, a multiple-trial
list-learning task. Verbal memory was negatively correlated
with age for younger men, older men, and older women, but not
for younger women. Multivariate analyses indicated age by gender
interactions on memory for the younger group but not the older
group. Results indicate that verbal memory declines with age
for younger men but not younger women, whereas both older men
and older women show age-related declines. These findings are
consistent with hypotheses linking estrogen and verbal memory
performance, and with imaging data suggesting that age-related
hippocampal atrophy is found in younger men but not younger
women. The role of estrogen on cognition in normal aging warrants
further study. (JINS, 2003, 9, 97–102.)
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health,Neurology (clinical),Clinical Psychology,General Neuroscience
Cited by
82 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献