Author:
HUONG V. T. L.,THANH L. V.,PHU V. D.,TRINH D. T.,INUI K.,TUNG N.,OANH N. T. K.,TRUNG N. V.,HOA N. T.,BRYANT J. E.,HORBY P. W.,KINH N. V.,WERTHEIM H. F. L.
Abstract
SUMMARYPorcine reproductive and respiratory syndrome (PRRS) outbreaks in pigs are associated with increased susceptibility of pigs to secondary bacterial infections, including Streptococcus suis – an important zoonotic pathogen causing bacterial meningitis in humans. This case-control study examined the association between human S. suis infection and PRRS outbreaks in pigs in northern Vietnam. We included 90 S. suis case-patients and 183 non-S. suis sepsis controls from a referral hospital in Hanoi in 2010, a period of major PRRS epizootics in Vietnam. PRRS exposure was determined using data from the National Centre of Veterinary Diagnosis. By univariate analysis, significantly more S. suis patients were reported residing in or adjacent to a PRRS district compared to controls [odds ratio (OR) 2·82, 95% confidence interval (CI) 1·35–5·89 and OR 3·15, 95% CI 1·62–6·15, respectively]. Only residency in adjacent districts remained significantly associated with risk of S. suis infection after adjusting for sex, occupation, and eating practices. SaTScan analysis showed a possible cluster of S. suis infection in humans around PRRS confirmed locations during the March–August period. The findings indicate an epidemiological association between PRRS in pigs and S. suis infections in humans. Effective strategies to strengthen control of PRRS in pigs may help reduce transmission of S. suis infection to humans.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Epidemiology
Reference29 articles.
1. Using the SaTScan method to detect local malaria clusters for guiding malaria control programmes;Coleman;Malaria Journal
2. Nguyen T . PRRS Control in the Region. Compendium of Technical Items of the 28th Conference of the OIE Regional Commission for Asia, the Far East and OceaniaWorld Organisation for Animal Health, 2013 (http://www.oie.int/publications-and-documentation/compendium-of-technical-items/). Accessed 16 March 2015.
3. Streptococcus suis:An Emerging Human Pathogen
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献