The effect of immunosuppressants on the development of Hymenolepis diminuta in mice

Abstract

Cortisone, methotrexate and anti-lymphocyte serum were all found to suppress the rejection by SPF CFLP male mice of H. diminuta, which normally occurs between days 9 and 12. Worms continued to grow in mice given immunosuppressants and matured on days 16–18 as they would in a rat, by which time they stretched from the stomach to, and sometimes into, the caecum. Worms in mice given methotrexate ceased to grow after day 16, but this was believed to be due to the deterioration of the host's intestine wall; in mice receiving cortisone growth was faster than normal and worms continued to increase in size until the end of the experiments on days 20–24. The mouse/H. diminuta system is discussed, emphasizing that, as far as is known, H. diminuta (which has no hooks) has no close contact with the tissues and that this is a case of a mammal responding against an organism living freely in the lumen.