Author:
Brett Sara J.,Cox F. E. G.
Abstract
SUMMARYThe intestinal flagellates,Giardia murisandSpironucleus muris, cause similar infections in CBA mice as determined by trophozoite and cyst counts. Both parasites occur all along the small intestine withG. muris, being mainly present in the anterior part andS. muristowards the posterior. The early stages of infection are similar in all strains of mice examined and peak levels of both trophozoites and cysts occur 1–2 weeks after infection. All strains of mice overcome the infection but the rate of recovery varies considerably between strains, being most rapid in BALB/c and slowest in A and C57BL.B10. Outbred mice are more variable in their recovery than inbred mice. After recovery, mice are partially resistant to reinfection with the homologous but not the heterologous parasite. Resistance to reinfection withS. murisis greatest in those strains that eliminate the primary infection most rapidly.Giardia murisandS. muriscause similar changes in the mucosa of the small intestine of BALB/c mice with increased intra-epithelial lymphocyte counts from 3 weeks onwards corresponding with the start of the elimination of the parasites from the gut. A reduction in villus height and increase in crypt depth is also characteristic of these infections.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Reference30 articles.
1. Defective tumoricidal capacity of macrophages from C3H/HeJ mice;Ruco;Journal of Immunology,1978
2. Synergistic role of intestinal bacteria in a post-weaning mortality of mice;Bookman;Laboratory Animal Science,1973
3. Genetic control of immunity to parasites: adoptive transfer of immunity between inbred strains of mice characterized by rapid and slow immune expulsion of Trichinella spiralis
4. Hexamitiasis in a laboratory mouse colony;Flatt;Laboratory Animal Science,1978
5. Suppression of giardiasis during the intestinal phase of trichinosis in the mouse.
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献